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pp.83-102
Effect of Gojanghwan on intestinal function was investigated in rabbit, making use of its water extract. Gojanghwan water extract(GW) made the motility and tension of ileum strips isolated from rabbit decreased. While it did not affect on the acetylcholine action, GW exhibited the significant inhibition on the actions of serotonin and histamin to ileum strips. In the longitudinal muscle of colon, GW suppressed the motility, but did not influenced significantly on the tension, and in the circular muscle of colon, GW showed the inhibitory effect on the motility and tension. GW inhibited markedly the actions(motility and tension) induced by acetylcholine, serotonin and histamine in the longitudinal and circular muscles of colon. According to the above results suggest that GW inhibited the intestinal function in rabbit, this inhibition was related to the various mechanism being induced by responses on the receptor of muscarine, serotonin and histamine.
