Anti-inflammatory effects of ethanolic extract of Angelica gigas (EAG 50, 150, and 500 mg/kg) were investigated in thermal burn-paw edema model. Immersion of rat hind legs into 48.5℃ water for 50 scincreased the leg volume by 0.46-0.55 ml. EAG attenuated not only the paw volume in a dose-dependent manner, but also blood lymphocyte counts and interleukin-6 level increased by burns, without influence on the level of tumor-necrosis factor-α. Moreover, EAG reduced alkaline phosphatase level, a parameter of hepatic injury, which was increased by thermal burns. The results indicate that EAG attenuates inflammatory aymptoms induced by thermal burn and EAG or its conmarin derivatives could be a promising anti-inflammatory drug candidate in inflammation diseases.

• Sunhee Shin(College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University)
• Dongsun Park(College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University)
• Jeong Hee Jeon(College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University)
• Jeong Seon Kim(Daejeon Health Sciences College)
• Sung Kyeong Park(Daejeon Health Sciences College)
• Yun-Bae Kim(College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) Corresponding author