Introduction Literally explosive is the growth of social media. The estimated number of monthly active Facebook users by the fourth quarter of 2016 is around 1.86 billion, almost a quarter of the world population, meaning that one in four people on the globe uses Facebook to read news, share gossips, communicate ideas, and build relationships with others. In the United States alone, 72% of all Internet users are reported to use Facebook (Pew Research, 2015), and to many, Facebook is no longer a small part of the Internet, but rapidly becoming the Internet itself. As peer-to-peer information sharing becomes a global mainstream, concerns about the credibility of information shared online is growing fast as well. With no gatekeeper in a traditional sense, rumors and fabricated information lacking reliable evidences (e.g., fake news) may spread wide and fast, and individuals are left alone to assess and judge which among them is likely to be true (Metzger, Flanagin, & Medders, 2010). Unfortunately, we know very little about how individuals assess information fed through online social networks, and how such processing of information in the social media environment differs from those in traditional media environment. In social media like Facebook where individuals and organizations interact through direct or indirect social relationships, what people can give and take is partly determined by with whom they have relationships and their locations in the entire network (Brands, 2014). For example, if one’s network consists mostly of college students, the network may be flooded with gossips, news, and information particularly appealing to them (e.g., how to pull an A from the hideous professor). If the network is made up of people from diverse backgrounds, meanwhile, the information shared therein will be as diverse as heterogeneous are the members’ characteristics and preferences. Network topology may, therefore, be a crucial factor that shapes not only what you encounter in your own network, but also the way you assess the information found therein (Sohn, 2014). An identical message may be construed differently depending on how it has been encountered (e.g., who liked/shared in Facebook) as well as where it originates (e.g., who are the original source of the message). For instance, the news regarding the effectiveness of alternative medicine on curing cancer may be assessed differently depending on whether it is shared by lay people with similar interest or medical experts, which subsequently affects one’s decision to share it. Whereas it is already well-founded that the original source quality plays an important role in communication (Visser & Cooper, 2007), relatively little attention has been devoted to unveiling the role of intermediate social environment lying between the original source and the final recipients. This study is aimed at examining systematically the role of social relations in individuals’ assessment of and decision to share information encountered in social media. More specifically, the focus will be on testing in an experimental setting how social relationship properties, reflecting psychological distance, shape individuals’ assessment of risk/benefit associated with the information received. Psychological Distance and Decision under Risk We are routinely exposed to a myriad of information from our immediate social circles including close friends and acquaintances as well as mass media. Some of them could be about the opportunities for earning extra profits (e.g., stock or real estate investment opportunities), while others about how to maintain better health (e.g., avoiding harmful chemical-intake). Whether it is about money, health or others, the decision to take an action on the information is a function of how to assess the risks involved. According to the prospect theory (Kahneman & Tversky, 1979), people have an inherent tendency of being more sensitive to the loss than benefit of anything, making them prefer avoiding loss to having an equivalent amount of gain. This loss-aversive tendency also implies that people prefer the possible to sure loss, even if the former is greater than the latter. In other words, people become risk-seeking to avoid any loss with certainty. Suppose, for example, you are given a choice between losing $750 for sure and doing a gamble such that you lose $1000 with 75% chance or lose nothing with 25% chance. Despite the identical expected value ($1000 x .75 + $1000 x 0 = $750), people tend to lean over to the gamble rather than the sure loss. This may work in the opposite way for benefit – you may prefer the sure to possible gain, meaning that you become risk-aversive when benefit is at stake. An interesting question is whether such a risk-seeking or aversion tendency is malleable (Tversky & Simonson, 1993). It is widely known that a message with identical contents can be construed differently depending on whether it is stated or framed in terms of benefit or loss (Slovic, 1995). Then, we might ask whether people construe messages differently depending on where they are from – whether they are from close-knit groups, distant acquaintances or some anonymous others. Prior studies have seldom considered such social contextual influence, which is essential to understanding communication in social media (Sohn, 2014). Suppose you are considering taking an alternative medicine for treating a chronic illness of yours, which will surely get worse with no treatment (i.e., loss with certainty). The alternative medicine’s effectiveness is largely unknown and has never been under rigorous scientific tests. You post your thought about adopting it and have just got replies from two different sources in your Facebook network – a close friend and a mere acquaintance. Your friend says that using the alternative approach can be detrimental to your health (i.e., loss frame), while the acquaintance mentions that s/he trusts the medicine’s benefits (i.e., benefit frame). What would be your choice given the comments? Would your choice be reversed if your friend says its benefit, while the acquaintance warns its side effects? It is posited in construal-level theory that “people use increasingly higher levels of construal to represent an object as the psychological distance from the object increases” (Trope & Liberman, 2010, p. 441). When there are pros and cons with respect to a course of action, people perceive cons (i.e., losses) psychologically closer than pros (i.e., benefits), which provides an explanation of why loss aversion occurs. In addition, it has been found that pros become more salient than cons as temporal distance to the action increases (e.g., buying a computer a year later; Eyal, Liberman, Trope, & Walther, 2004). Taken together, it may be inferred that the cons are salient when the action of interest is thought psychologically proximal, but the pros become more salient as it gets more psychologically distant. This inference can be applied to other distance dimensions including social distance as well. Combining benefit-loss frames and social distance perceptions, we can come up with the following four different conditions as summarized in Table 1. With all other things held equal, people tend to feel loss psychologically closer than benefit. However, the salience of either benefit or loss in a person’s mind may also depend on how the information is presented -- whether a message with the information comes from a proximal or distant source. For example, if a message with emphases on an alternative medicine’s benefit came from a proximal source (BP), further decrease in psychological distance might make salient its potential side effects, and thus lessen the benefit’s influence on decision. Similar inferences can be made to the case when a message with emphases on loss came from a distant source (LD). Due to the increase in psychological distance, it might become difficult to think of the negative aspects of the target (Herzog, Hansen & Wanke, 2007). If the message emphasizing either benefit or loss is aligned respectively with a distal (BD) or proximal source (LP), in contrast, they will become more salient in the person’s mind, which would exert a disproportionate influence on decision. Given the discussion, the following hypotheses can be proposed: H1a. People perceive the benefit more salient, and thus are more likely to make a risky choice when it is supported by socially distant others than when no information of the social distance to the source is given (i.e., control condition). H1b. People perceive the benefit less salient, and thus are less likely to make a risky choice when the benefit is supported by socially close others than when no information of the social distance to the source is given (i.e., control condition). H2a. People perceive the loss more salient, and thus make a risky choice less when the loss is warned by socially close others than when when no information of the social distance to the source is given. H2b. People perceive the loss less salient when the loss is warned by socially distant others than when no information of the social distance to the source is given. Experimental Design A 2 (message frames) x 3 (social distance) between-subjects online experiment will be conducted as follows. Subjects will be given multiple hypothetical risky choice situations with respect to such issues as making an investment, adopting a new medical treatment, purchasing a product. After being exposed to the choice scenarios, they will be asked a series of questions for measuring their issue-involvement levels, attitudes to the issue presented, thoughts related to benefits and losses, and final choices, along with relevant psychological and demographic characteristics. Implications No communication ever occurs in a social vacuum. Just as our everyday behaviors are shaped and often constrained by the physical places in which they are performed (e.g., rooms, streets, buildings), we communicate in a social setting consisting of direct and/or indirect relationships among people (Gifford, 2013). The knowledge of one’s social surroundings becomes more important in social media due to the manifest location dependency—meaning one’s position in a relationship network basically defines what can be seen and done. No matter whether information originally came from a newspaper, television program, or blog, the information is eventually transmitted via one of the network members, highlighting the importance of relationship patterns and qualities in communication processes. That is, in any socially-networked environment, people rely not only on inferences about the original source quality (e.g., authority, expertise), but also on the social contexts through which the information is received and shared. Most previous research has focused mainly on the former (i.e., source quality) while overlooking both the latter (i.e., social contexts) and any possible interactions between the two (Metzger, Flanagin, & Medders, 2010). The current study is believed to bridge the gap so that communication processes in the social media environment could be understood in a more systematic fashion.

This research was conducted in order to examine whether the type of credit card (premier vs. standard card) influences consumer purchase decisions regarding luxury consumption. The present research reports three experiments with online panels of non-student adults, which find that (1) the use of a premier card (vs. a standard card) leads to a more goal-congruent choices, (2) the effect is mediated by a temporary increase in the perception of pride, and (3) the effect is pronounced for people with a low level of chronic pride. The effect of payment methods on consumer spending has been a concern of theory and research in consumer behavior (Bernthal, Crockett, & Rose, 2005; Feinberg, 1986; Prelec & Lowenstein, 1998; Soman, 2001). This research stream has shown that consumers tend to spend more when they use a credit card than when they pay cash and has proposed various theoretical mechanisms to account for the phenomenon (Chatterjee & Rose, 2012; Prelec & Simester, 2001; Soman, 2001; Thomas, et al., 2011). However, researchers have paid little attention to the effect of different types of credit cards (i.e., premier vs. standard card) on consumer decisions. We contend that the use of a premier card (vs. a standard card) can increase the feeling of pride momentarily and in turn increase consumers’ motivation to pursue a long-term goal that they value. As a result, they prefer a choice alternative that is more congruent with the goal. To be specific, the use of a premier card would increase the choice of luxury alternative, and that this effect would be pronounced for those who value material possessions (i.e., high materialism). This expectation was confirmed in the studies that we have performed. In three experiments, participants were shown a credit card(either premier or standard) and were asked to assume that they were going to use it for their purchase. Then, they were asked to make choices in shopping contexts. Participants with premier credit card, compared to those with standard card, showed more goal-consistent choices. They were more likely to choose luxury alternatives, and this effect was apparent only for those who have a high materialistic value. When the choice set includes both a low-calorie food and a high-calorie food, the use of a premier card increased the choice of low-calorie food, and this effect was apparent only for those with diet goal. These effects were mediated by the feeling of pride. Three studies in combination provide insights into the effect of types of credit cards on consumer spending regarding luxury consumption and the processes underlying the effect, which have not been reported elsewhere. The use of a premier credit card (vs. a standard credit card) led to a greater choice of luxury alternatives over standard alternatives and a greater choice of low-calorie foods over high-calorie foods. However, these effects were apparent only when people highly valued the goal under consideration (i.e., high materialism or strong diet goal). Finally, these effects were attributable to a momentary increase in the perception of pride by virtue of the use of a premier card, and consequently, the effects were observable only for people who have a relatively low chronic pride. The effects we observed in this research generalized over different product categories and different long-term goals. Nevertheless, it is desirable to extend findings in more diverse consumption categories (e.g., services) as well as to identify additional variables that moderate the magnitude of the effect. In addition, it is worth considering alternative underlying mechanisms than the one we considered (i.e., the feeling of pride) in future research. For example, a premier card may increase individuals’ construal level, thereby affecting consumer purchase decisions.

This research examines how advertising message effectiveness differs depending on media types that provide fashion information among teenagers. Employing cloth consumption value and ‘fitness’ of fashion style, young people’s attitudes toward advertising and brand of fashion product were analyzed. Theoretical contribution and practical implication for fashion industry are discussed. Introduction Teenagers are an important consumer group in the clothing market, and the market size is expanding. They are more likely to absorb new information and respond to social influences, compared to other age groups. Thus, it is expected that teenagers are greatly influenced by the fashion information gained when making a purchase decision. In adolescence, the peer group is especially influential, as well as the media. Therefore, it is possible that their use of information source will differ from other groups. The most popular medium for Korean teenagers in recent years is social media. A Social Network Service (SNS) is a web-based service that allows individuals to build social relationships, providing a place for users to exchange information and opinions by providing a platform for communication (Boyd & Ellison, 2007). As development of mobile Internet technology, smart phone or tablet PC is commonly used in Korea and SNS becomes vital way for communication for young people. Most of teenagers are using SNS daily and exchanging their opinion each other. Recently, it attracts increasing attention for marketers to deliver advertising messages as a new marketing tool. Fashion companies widely employ SNS in their marketing activities to enhance brand images, retain customers (Cho & Park, 2012). SNS serves as a platform for “many-to-many” interactive communication, unlike traditional mass media for ‘one-to-many’ communication. Unlike traditional media, SNS has a wider influence on participants. Therefore, exactly the same message could be differently functioned by the advertising delivering system. This study seeks to look at how message effectiveness differs depending on the type of media that provides fashion information. As mentioned earlier, social media has distinct characteristics from the traditional mass media. Thus, even when it is the same advertising information, its impact on the consumer can vary when transmitted through the mass media and through social media. In addition, social media is a collection of various social platforms that share specific properties rather than a single media. Thus, depending on the type of social media, the same ad information can also be expected to elicit differing responses from consumers. In this study, female youth were studied as subjects of research. The survey method was utilized. This will allow us to explore the impact of various media on female youth's response on fashion advertisement. Understanding the sources of information important in youth will help develop effective clothing products marketing. The use of clothing sources varies depending on the group. Therefore, each vendor is expected to establish effective marketing methods through research on the use of the clothing information sources of the target audience. Theoretical Background Type of Media In this study, type of advertising media was mainly categorized as follows: Social Network Service (SNS) and mass media. More specifically, SNS was reassigned into three by characteristics of service such as network-type, share-type, and blog-type (Chung & Lee, 2015). Overall, four types of media were analyzed in this study and each service was represented by Facebook, Instagram, Twitter, and magazine ad in the order named. Social Desirability and SNS Along the development of Internet based technology (IT), ways of advertising placement became diverse and moved focus on IT based service including SNS. Especially for young people, fashion industries are willing to catch their eyes on SNS. By the nature, young SNS users are eager to search, blog, and share what they have earned on SNS for various reasons. Sharing fashion information is very important for young female. Their expressions on SNS mean what they are; what I eat, wear and so on. A fellow feeling, so called ‘we-ness’, is extremely essential for Korean young people. Looking alike does not only share collectivistic spirits, but also makes feel not fall behind the trendy style. Using SNS is one of the best ways of confirming their fellow feeling and at the same time it reduces peer pressure. From the domain of fashion marketing, research on communication had been mostly focused on mass media, and research on SNS communication, sharing of consumption information among consumers had been insufficient (Jun & Park, 2013). Fashion companies are recently trying to utilize SNS as a new alternative to have efficient effects with little costs. The SNS communication effect plays a large role in the consumption of consumers and analyzes the influence of SNS on the responses of the customers. SNS has the characteristic in which recommendations of friends or reliable acquaintances based on trust are important (Jung & Cho, 2016). Fashion Information Source and Clothing Consumption Value Consumers’ choice of clothing is based on the information gained. Information provided by the media or other people's clothing is the main source of decision making. In this case, the media and the surrounding people will become sources of desirable fashion style. Earlier, Cox(1967) classified the type of information sources as marketer-driven sources, consumer-driven sources, and neutral sources. Several scholars classified information sources as personal and non-personal sources, and direct observations and experiences (Andreasen 1968, Sproles 1979). Park and Yoo(2000) classified consumers according to fashion lifestyles and analyzed the sources of information that each group utilized. Each group tended to use different types of fashion information sources. Fashion-following group and personality-oriented group utilized more media and personal information, such as print media and television, compared to pragmatism group and conformity group. Personality-oriented group tends to use more direct observation than other groups. Conformity group showed the least use of mass media, purchase experience, observation, and interpersonal information source. This result shows that the types and degree of information used varies depending on the consumer’s fashion lifestyle. Research has found that clothing consumption value is one of the major variables which affect consumer’s use of information source. Among several classifications of consumption values, Sheth’s model is the most utilized model in Korea fashion academia (Han and Kim, 2002). Sheth et al. (1991) classified consumption values into functional value, social value, emotional value, epistemic values, and conditional value. Han and Kim (2002) classified consumer groups into 4 groups utilizing Sheth’s classification: the Conspicuous, the Epistemic, the Social/Conformitive, and the Indifferent. There were significant different among the four groups in information search process. The Conspicuous and the Epistemic more tend to search carefully the clothes inside the store or in the show window than other groups. The two group members answered that they make a decision based on my own tastes than the other groups. Research Questions and Hypotheses Based on the earlier discussion, we propose following research question and hypotheses. Research Question 1: Would advertising message’s effect on young people’s attitudes toward advertising and brand of fashion product be different, depending on their consumption value of clothing? Hypothesis 1-1: Consumers in different consumption values groups will show different response to the same advertising message delivered through different channels. Specifically, social conformity group are more likely to show positive attitude toward advertising and brand presented on network-type SNS than advertising and brand presented on other platforms. Hypothesis 1-2: The Expressive is more likely to show positive attitude toward advertising and brand presented on magazine than other groups are. Research Question 2: Would advertising message’s effect on young people’s attitudes toward advertising and brand of fashion product be different, depending on their age group? Hypotheses 2-1: Young women will have better responses to SNS-based ads than magazine ads to older women. Research Question 3: Would advertising message’s effect on young people’s attitudes toward advertising and brand of fashion product be different, depending on their perception of ‘fitness’ of their desired fashion style? Hypotheses 3-1: When they perceive the presented style on the ad does not fit to their desired fashion style, network-type SNS is more likely to get positive attitude from the social conformity group than from the other groups. Methodology This present study aims to investigate the effects of advertising message by operating delivering system on consumers’ attitude toward fashion advertising and purchase intentions. This research employed a 4 (consumption value of clothing: expressive, practical, unique, social/conformity) X 4 (Advertising media type: network-type SNS, share-type SNS, blog-type SNS, and magazine) X 2 (fashion style fitness: fit/not fit) between subjects factorial design. The survey was conducted on 200 more young females, aged 16 to 24. Main Discussion Points This study aims to investigate how a fashion product ad works depending on the type of media on which the fashion advertising presents. To do this, authors will compare the advertising effectiveness among magazine ad, Facebook (Network type SNS), Instagram (Share type SNS), and Twitter(blog type SNS). First of all, we are going to examine how each advertising medium works depending on consumer’s consumption values, their age, and the perception of fitness of their desired fashion style. Based on the results, the theoretical contribution and practical implication will be discussed. This discussion will provide us deeper understanding on how fashion industry utilizes advertising media when female youth is a major target group

A consumer is an individual entity with various motivations. This study is intended to incorporate a hierarchical structure of motivation to understand self-determined motivation for purchasing secondhand merchandise at thrift stores. A conceptual model adopted from Cadwallader et al. (2010)’s comprehensive model of motivation used in a marketing context was developed to investigate motivational process in secondhand merchandise shopping. The conceptual model includes the three levels of motivational structure–the global, contextual (environmental concern and frugality), and situational motivation. A series of the causal relationships among the three levels of self-determined motivations and buying intention to shop at thrift stores were hypothesized. A total of 219 respondents from two different northeastern state universities in the U.S. completed a self-administered survey. The results indicated that secondhand merchandise shopping is well explained in the hierarchical structure of self-determined motivation where the global motivation had a positive impact on the contextual motivations regarding environmental concern and frugality. Of the two contextual motivations, only environmental concern had a positive impact on situational motivation for shopping at thrift stores. Finally, the situational motivation positively influenced the intention to shop at thrift stores. The results of this model suggest that the hierarchical structure of self-determined motivation would be a very useful framework to understand consumer behavior for apparel shopping. Also, further research can be done to identify other contextual motivational factors to understand consumer motivation for shopping at thrift stores.

Fe-6.5 wt.% Si alloys are widely known to have excellent soft magnetic properties such as high magnetic flux density, low coercivity, and low core loss at high frequency. In this work, disc-shaped preforms are prepared by spark plasma sintering at 1223 K after inert gas atomization of Fe-6.5 wt.% Si powders. Fe-6.5 wt.% Si sheets are rolled by a powder hot-rolling process without cracking, and their microstructure and soft magnetic properties are investigated. The microstructure and magnetic properties (saturation magnetization and core loss) of the hot-rolled Fe-6.5 wt.% Si sheets are examined by scanning electron microscopy, electron backscatter diffraction, vibration sample magnetometry, and AC B–H analysis. The Fe-6.5 wt.% Si sheet rolled at a total reduction ratio of 80% exhibits good soft magnetic properties such as a saturation magnetization of 1.74 T and core loss (W5/1000) of 30.7 W/kg. This result is caused by an increase in the electrical resistivity resulting from an increased particle boundary density and the oxide layers between the primary particle boundaries.

In this work, p-type Bi−Sb−Te alloys powders are prepared using gas atomization, a mass production powder preparation method involving rapid solidification. To study the effect of the sintering temperature on the microstructure and thermoelectric properties, gas-atomized powders are consolidated at different temperatures (623, 703, and 743 K) using spark plasma sintering. The crystal structures of the gas-atomized powders and sintered bulks are identified using an X-ray diffraction technique. Texture analysis by electron backscatter diffraction reveals that the grains are randomly oriented in the entire matrix, and no preferred orientation in any unique direction is observed. The hardness values decrease with increasing sintering temperature owing to a decrease in grain size. The conductivity increases gradually with increasing sintering temperature, whereas the Seebeck coefficient decreases owing to increases in the carrier mobility with grain size. The lowest thermal conductivity is obtained for the bulk sintered at a low temperature (603 K), mainly because of its fine-grained microstructure. A peak ZT of 1.06 is achieved for the sample sintered at 703 K owing to its moderate electrical conductivity and sustainable thermal conductivity.

Background:After a stroke, the control of the trunk muscle may be severely impaired. Due to the importance of trunk control in complex daily postures, the ability to adopt a correct sitting posture is considered a determinant of the recovery of independent function after a stroke.Objects:The purposes of this study were to compare differences in buttock pressure between the left and right sides of hemiplegic patients and differences in their pelvic tilting angles (sagittal and coronal planes) after sitting training with visual biofeedback (VBF) in real time.Methods:Twenty-two individuals with unilateral strokes (11 left-side and 11 right-side hemiplegic stroke patients) participated in this study. Buttock pressure was measured using a pressure mat, and pelvic angles were measured using a palpation meter.Results:The asymmetry of pressure between the right and left (first and third chamber) sides was significantly decreased after the VBF training. The measurements obtained using the palpation meter revealed a significant decrease in the pelvic angles pre- versus post-intervention.Conclusion:VBF training may be distribute a patient’s buttock pressure equally while in a sitting posture and increase the length of time a stroke patient can maintain a symmetrical sitting posture. It can also improve pelvic control while sitting in a neutral position.

Embryo transfer (ET) could be a relevant tool for genetic improvement programs in horses similar to those already underway in other species and produce multiple foals from the same mare in one breeding season. However, there have been no reports describing equine embryo transfer performed in Korea. In the present study, we performed an equine embryo collection and transfer procedure for the first time. We examined the embryo collection and pregnancy, size of embryo during the incubation period after collection, and progesterone (P4) and estradiol-17ß (E2) concentrations in mare’s serum at embryo collection and transfer. A total of 16 donors responded to estrus synchronization; estrus was induced in 12 donors and 4 recipients, and artificial insemination was successful in 10 donors and six blastocysts were collected from donors. Of these blastocysts, we monitored the size of blastocysts for 3 day during incubation and transferred 2 blastocysts to a recipient, with 1 successful pregnancy and foal achieved. The dimensions of equine embryo at day 7 to day 9 were 409 μm, 814 μm and 1,200 μm. The serum P4 and E2 concentrations were 7.91±0.37 ng/μL and 45.45±12.65 ng/μL in the donor mare, and 16.06±3.27 ng/μL and 49.13±10.09 ng/μL in the recipient mare.

It is very difficult to get the information about semen quality analysis in transgenic pigs because of limited numbers and research facilities. Therefore, in the present study, we analyzed the semen quality of transgenic boars generated for xenotransplantation research. Briefly, the semen samples were collected from 5 homozygous α1,3-Galactosyltransferase knock-out (GalT-/-) transgenic boars and immediately transported to the laboratory. These semen samples were decupled with DPBS and conducted to analyze semen parameters by a computer-assisted semen analysis (CASA) system. The boar semen were examined all 12 parameters such as total motility (TM), curvilinear velocity (VCL), straight line velocity (VSL), average path velocity (VAP), and hyperactivated (HYP), etc. In results, among the 5 GalT-/- boars, three boars (#134, 144, and 170) showed normal range of semen parameters, but #199 and 171 boars showed abnormal ranges of semen parameters according to standard ranges of semen parameters. Unfortunately, #171 boar showed azoospermia symptom with rare sperm counts in the original semen. Conclusively, assessment of semen parameters by CASA system is useful to pre-screening of reproductively healthy boar prior to natural mating and artificial insemination for multiplication and breeding.

The p21-activated kinases (PAKs) are a family of serine/threonine protein kinases and activated by binding with activated Rho GTPases such as Rac or Cdc42. PAKs regulate actin cytoskeletal remodeling, cell motility, cell survival, and apoptosis. Also, PAKs are involved in several diseases such as cancer, virus infectious diseases, mental retardation, Alzheimer and Parkinson's diseases. Therefore, the substances that are able to inhibit PAK activation can be used as powerful tools and medicines for PAK relative diseases or specific inhibitors for study of PAK signaling pathway. In this study, we investigated and characterized the 5 compounds of 4-benzene-1, 2-naphthoquinone (NQ) family as candidate substances to inhibit the PAK1 activation in vitro and in cells. Binding between p21-binding domain (PBD) of PAK1 and Cdc42 was blocked by 5 NQ-compounds in ELISA assay. Myelin basic protein (MBP) phosphorylation was dramatically reduced by treatment of these compounds in vitro kinase assay for Cdc42-induced or constitutive active PAK1 mutant. Also, phosphorylation at Thr 423 of transfected PAK1 was inhibited by treatment of 5 NQ-compounds in 293T cells, respectively. Finally, NQ-5 inhibited strongly the PAK1 activation by PDGF stimulation and cell motility in PDGF-induced wound migration assay in NIH 3T3 cells. Therefore, these NQ compounds will be good candidates as target molecules to regulate PAK1-related diseases or inhibitors to study PAK1 signaling pathway.

We conduct BVRI and R band photometric observations of asteroid (5247) Krylov from January 2016 to April 2016 for 51 nights using the Korea Microlensing Telescope Network (KMTNet). The color indices of (5247) Krylov at the light curve maxima are determined as B - V = 0:841  0:035, V -R = 0:4180:031, and V -I = 0:8710:031 where the phase angle is 14.1◦. They are acquired after the standardization of BVRI instrumental measurements using the ensemble normalization technique. Based on the color indices, (5247) Krylov is classied as a S-type asteroid. Double periods, that is, a primary period P1 = 82:188  0:013 h and a secondary period P2 = 67:13  0:20 h are identied from period searches of its R band light curve. The light curve phases with P1 and this indicate that it is a typical Non-Principal Axis (NPA) asteroid. We discuss the possible causes of its NPA rotation.

Metformin (1,1-dimethylbiguanide hydrochloride), derived from French lilac (Galega officinalis), is a first-line anti-diabetic drug prescribed for patients with type 2 diabetes. However, the role of metformin in odontoblastic cell differentiation is still unclear. This study therefore undertook to examine the effect of metformin on regulating odontoblast differentiation in MDPC-23 mouse odontoblastic cells derived from mouse dental papilla cells. As compared to controls, metformin significantly accelerated the mineralization, significantly increased and accelerated the expressions of ALP and Col I mRNAs, and significantly increased the accelerated expressions of DSPP and DMP-1 mRNAs, during differentiation of MDPC-23 cells. There was no alteration in cell proliferation of MDPC-23 cells, on exposure to metformin. These results suggest that the effect of metformin on MDPC-23 mouse odontoblastic cells derived from mouse dental papilla cells, facilitates the odontoblast differentiation and mineralization, without altering the cell proliferation.

In this study, magnetite (Fe3O4) nanoparticles were electrochemically synthesized in an aqueous electrolyte at a given potential of -1.3 V for 180 s. Scanning electron microscopy revealed that dendrite-like Fe3O4 nanoparticles with a mean size of < 80 nm were electrodeposited on a glassy carbon electrode (GCE). The Fe3O4/GCE was utilized for sensing chloramphenicol (CAP) by cyclic voltammetry and square wave voltammetry. A reduction peak of CAP at the Fe3O4/GCE was observed at 0.62 V, whereas the uncoated GCE exhibited a very small response compared to that of the Fe3O4/GCE. The electrocatalytic ability of Fe3O4 was mainly attributed to the formation of Fe(VI) during the anodic scan, and its reduction to Fe(III) on the cathodic scan facilitated the sensing of CAP. The effects of pH and scan rate were measured to determine the optimum conditions at which the Fe3O4/GCE exhibited the highest sensitivity with a lower detection limit. The reduction current for CAP was proportional to its concentration under optimized conditions in a range of 0.09-47 μM with a correlation coefficient of 0.9919 and a limit of detection of 0.09 μM (S/N=3). Moreover, the fabricated sensor exhibited anti-interference ability towards 4-nitrophenol, thiamphenicol, and 4-nitrobenzamide. The developed electrochemical sensor is a cost effective, reliable, and straightforward approach for the electrochemical determination of CAP in real time applications.

The ability of plants to endure environmental stress factors, which are going to be more severe due to global warming, is important especially for forest plants. Because obtain trait of resistance to temperature using conventional breeding for woody plants is a time consuming way. In this study, chloroplast-localized OsHSP26 gene was overexpressed in Populus alba L. to breed tolerant transgenic poplar to temperature stress. The plantlets of OsHSP26-overexpressed transgenic poplar showed more heathy phenotypic response than wild-type plants under both prolonged low- and high-temperature stress. While the SPAD value, which refers chlorophyll content, in wild-type plants decreased depending on the exposure time to the temperature stress, higher SPAD value were shown in the transgenic plants. The contents of total phenolic compounds in the transgenic plants were lower than those of the wild-type plants, and not significantly changed except in the treatment of prolonged low-temperature. However, the total flavonoids contents of the transgenic plants were dramatically increased under prolonged temperature stress. The DPPH scavenging activities of the transgenic plants were higher than those of the wild-type plants under temperature stress. Consequently, it was revealed that overexpressing OsHSP26 allow for P. alba to be tolerant to temperature stress.

Effective estrus detection and artificial insemination (AI) are necessary for profitable management of dairy herd. In current study, 45 crossbred lactating cows have been selected with the complaint of unobserved oestrus for more than sixty days postpartum. All cows had functional corpus luteum as examined by transrectal ultrasonography. Cows were treated with PGF2α analogue and AI was performed with observed oestrus and then single dose of GnRH was administered. Similar synchronization protocol has been repeated after 14 days in cows that did not repose to first treatment. Remaining cows received additional PGF2α after 14 days of second treatment and timed AI was performed following GnRH administration. Among 45 cows, 28.89% showed estrus after first treatment and 78.79% responded to second hormonal intervention. A higher conception rate (88.89% vs 26.66 and 72.72%) was observed in cows after triple administration of PGF2α and timed AI. We noticed a significant differences in body condition score (BCS, 1～5 scale), postpartum period, and daily milk production between cows that either responded of non-responded following first and second hormonal treatment. In addition, there was a significant positive correlation between daily milk production and BCS, age and postpartum days, milk production and estrus/BCS, and milk production/BCS/estrus and conception rate. Depending upon the findings we conclude that hormonal intervention with PGF2α and GnRH enhances postpartum ovarian cyclicity and help decreasing the days open of dairy herd. Therefore, this finding might provide an excellent guideline for target breeding system for profitable dairy herd management.

The purpose of this study is to investigate and characterize the visual preferences of Rural Housing Standard Plans, which are expected to increase in demand as the number of households grows, and the effects of those characterizations on people’s choices in selecting home plans. In this study, Munsell values were extracted and analyzed using color analysis, and I.R.I image adjective analysis was performed to identify the color characteristics of each model type. To analyze the effect of the most influential colors among the visual elements in the plans, questionnaires were carried out according to whether color was present or not. There was a correlation between pre-selected frequency of preference and preference of visual preference. The study tallied the number of downloads for each model provided for the site of the farmers’ village and applied a t-test to confirm whether there was a difference in visual preferences. The results were as follows. First, the colors of Rural Housing Standard Plans were N and YR series, and the image analysis results were “Oriental” and “Rural”. Second, analyzing the number of model downloads and visual preferences on the homepage (www.returnfarm.com). Third, in the results of visual preference, the wooden house ranked 2.98-5.13 and the reinforced concrete house ranked 3.68-4.48. Fourth, comparative analysis of selection frequency and visual preference showed that the rankings of the top-ranked plans were similar; all were wooden houses and had similar roof forms. Fifth, the t-test conducted to analyze preferences in the visual elements of the standard design model of rural housing revealed significant differences in preferences for the color, roof form, and size, but no statistically significant differences (at .111) between preferences for structural wooden and reinforced concrete. The reason for this was that the types of wooden and reinforced concrete were not clearly distinguished from each other by photographs. Therefore, analysis suggested that the visual factors influenced the preference of Rural Housing Standard design model. In conclusion, it is necessary to present a model considering visual factors when providing models to urban and rural residents.

Abstract2)The incidents of garbage dumplings in 2004 and the report on giant castella are the examples that shows how big the influence of broadcasting on the industry is. There were discussions on the importance of securing the objectivity of broadcasting, however, the existing related researches have lacked the analysis of actual proof for the influence of broadcasting contents, and as that of the law and system was confined to theoretical arguments, there were not enough suggestions for realistic alternatives. In this paper, we will examine the influence of broadcasting contents on the food industry through an analysis of actual proof, and propose alternatives in terms of the law and policy for securing the objectivity and fairness of broadcasting, to solve this problem.

Purpose: Diabetes is a metabolic disease that occurs when the pancreas does not produce enough insulin (Type I diabetes) or when the body does not effectively use the insulin (Type II diabetes). One of the most common complication of diabetes is diabetic retinopathy(DR). DR is a time-dependent disease and induces blindness. DR produces reactive oxygen species (ROS) and superoxide is mainly made from mitochondria electron chain and it is harmful to eyes. Methods: In this study, eyes were enucleated from glucose-immersed zebrafish which is good model to generate diabetes and then mitochondria were isolated to evaluate activities of mitochondria electron transfer complex. Activity of mitochondrial electron transfer complex in eyes was measured by UV-vis spectrometer. Results: After the glucose immersion, the amount of mitochondria in eyes was increased compared to non-glucose-immersed zebrafish. Mitochondrial complex I, II, III, and IV activities of glucose-immersed zebrafish was improved compared to non-glucose-immersed zebrafish. Conclusions: These results indicated that 3 days or 7 days glucose immersion on zebrafish to induce the early stage of diabetes on zebrafish. Zebrafish might contribute to metabolic compensatory mechanisms in eyes to restore their mitochondrial homeostasis on the early stage of diabetes.

Current marine navigational practice relies less on long-range visual marine signals such as lighthouses for reference purposes. This is due to the availability of Global Navigation Satellite Systems (GNSS), which are integrated with other navigational aids on ships. Therefore, the objective of this study is to review the function of Pisang Island lighthouse and to propose the most relevant use of Pisang Island for current navigational needs. The function of the lighthouse was reviewed according to the IALA Navigational Guide and the AIS data image. The result showed that the most suitable navigational use of the lighthouse is to act as a reference for Line of Position (LOP). The AIS data image indicated that mariners are not using Pisang Island lighthouse for LOP. The trend in the Straits of Malacca (SoM) was compared with the trend in the Straits of Dover, UK. The selected experts verified that LOP was not practised there. As a specific example, a tanker ship route in the South China Sea was used to further support that LOP was not practised. This evidence supported the view that Pisang Island lighthouse is less relevant for current navigational practice and does not directly support the coastal state VTS operation and the establishment of the marine electronic highway. Furthermore, the existing shore-based VTS radar has limitations on range and the detection of targets near Pisang Island. Therefore, this study proposes the establishment of a new radar station on Pisang Island at the existing site of the lighthouse. The proposed new radar station on Pisang Island will add to the existing coverage of the VTS radar, bridging the coverage gaps to overcome the weakness of the existing shore-based radar and improve the safety and security of marine navigation in the SoM.

Hart, William, Suh, Kyunghee, & Oh, Yeonglim. 2017. “OK in Emergency Dispatch Encounters”. The Sociolinguistic Journal of Korea 25(2), 1~28. This paper investigates the discourse marker OK in 911 emergency calls, paying special attention to how its use is embedded in the context of the request-offer sequence through which the caller and the dispatcher display distinctive orientations in terms of goals, rights, and responsibilities. In line with previous research, it was found that the use of this marker displays multifunctionality, which for callers is manifested in the function OK not only as a response token but also as an affiliative signal of cooperation in the acknowledgment and acceptance of directives and updates on the status of the emergency response. For dispatchers, this multifunctionality is found in the activation of a bidirectional looking function of the marker which orients backward in acknowledgment of information elicited and provided in previous turns, while simultaneously orienting forward in anticipation of an impending directive, request for information, or status update in the turn that follows.