There is a view in the scholarly community that although the Codex Yupian (卷軸本《玉篇》) was a detailed text with many explanations, it neglected the phonetic-meaning relations. Taking the Codex Yupian as the research material, we analyze the phonetic-meaning relations of the initial tone of one phonetic, initial tone of one phonetic+youyin (又音), initial tone of two phonetics, initial tone of two phonetics+youyin, initial tone of three phonetics, and no phonetic entries, and analyze the relations between phonetic and meaning in the context of literature, The similarities and differences in the meanings of the items, and the comparison with the Daguang Yihui Yupian (《大廣益會玉篇》), Jingdian Shiwen (《經典釋文》) and Codex Yupian, as well as the source of youyin and the corresponding relationships between phonetics and meanings, to illustrate that Codex Yupian edited by Gu Yewang (顧野王) has a very complicated explanation. This study shows that Gu Yewang had a clear explanatory style and a matching relations between sound and meaning, and that the emergence of multiple sounds and multiple meanings. It is the result of Gu Yewang’s “summarizing all the texts and studying all the classics” and “studying the Six Classics and studying all the Hundred Books”, and it is the result of the fusion of the peoples of the North and South Dynasties. It is also the result of the development of language under the ethnic fusion of the North and South Dynasties and the compilation of the literature of the time. The book plays an important role in standardizing and clarifying the relationship between morphology, phonology and meaning during the North and South Dynasties.