This paper studied two factors for the manufacturing companies whose number of employee are under three hundred. One is the effect of the observation of quality system under the CEO's interest degree of quality management. First, most of company answered acquiring certificate ISO 9000 is very helpful for the company management .therefore the company have competence for the change of economic environment of domestic and international economy. Second, after acquiring the certificate ISO 9000, there were many improvements in company culture, quality control and business process productivity. As a result, acquisition of certificate of ISO 9000 system makes the company culture preparing the future to become a world first class company.