This study deals with the application of an artificial neural network (ANN) model to predict power consumption for utilizing seawater source heat pumps of recirculating aquaculture system. An integrated dynamic simulation model was constructed using the TRNSYS program to obtain input and output data for the ANN model to predict the power consumption of the recirculating aquaculture system with a heat pump system. Data obtained from the TRNSYS program were analyzed using linear regression, and converted into optimal data necessary for the ANN model through normalization. To optimize the ANN-based power consumption prediction model, the hyper parameters of ANN were determined using the Bayesian optimization. ANN simulation results showed that ANN models with optimized hyper parameters exhibited acceptably high predictive accuracy conforming to ASHRAE standards.