Large enclosure means a space of high ceiling and large floor. Designing the heating system, many thermal conditions exist, such as thermal comfort, IAQ, heating load and energy efficiency etc. The prediction of the temperature distribution is carried out according to some of the diffuser angle. The simulation conditions are 7 m high diffuser, 4/2 inlet/outlet diffusers, 39 °C discharge air temperature, and 6 m/s exit velocity. The results show that 45° diffuser provides an optimal thermal environment, and the reason is that the temperature is closed to the designed temperature 22 °C at 1.18m elevation plane. As the diffuser angle is decreased, the temperature of the upper region is increased for the thermal buoyancy effect. And the asymmetry of the temperature distribution is increased.