The purpose of this study is to examine the prevalence of musculoskeletal disorders and ergonomic risk factors for workers of printing business. A self-reporting survey and task analysis using video camera were performed to identify ergonomic risk factors associated with musculoskeletal disorders. We used the OWAS, RULA, and REBA methods to quantify the risk factors, and the results show that the printing business have high risk of work-related musculoskeletal disorders.