Potting media are an integral part of potted plants production system, formulated by a mixture of various raw materials to act as a substrate for plant support and source of nutrition. There is a wide range of potting media available, which are used for quality production of high-value plants worldwide. In this study, quality assessment of Dracaena plants grown in different potting media like: mushroom compost, peat, sand, farmyard manure, coconut coir, and leaf compost in different combinations were carried out. A mixture of sand, mushroom compost, coconut coir, and peat proved to be the best, by promoting root and shoot growth, leaf area, fresh and dry weights of root and shoot, and also improved overall quality of the plant. Media containing garden soil alone or a mixture of sand and leaf compost produced the lowest quality of plants with considerable reduction in most of the growth parameters. Anatomical parameters showed weak relation to media composition as compared to other morphological features. The best medium was made with sand, mushroom compost, coconut coir, peat, that produced plants with thick epidermis and larger pith cells, but thin endodermis and smaller metaxylem vessels in their roots. As moisture availability was sufficient enough in this medium combination, the development of water storing tissue may not contribute significantly. However, epidermis can play a decisive role in protecting roots from external environmental hazards.