Effective phytosanitary fumigation can prevent the introduction of exotic insects into new areas where they become pests. Traditionally Probit 9 level control (99.9968%) was considered as a stand-alone quarantine treatment. However, unacceptable phytotoxic damage often associated with high-dose treatment to realize Probit 9 level control of a large number of pests has often restricted its practical application. Therefore, quarantine security is being achieved for some commodities using a “systems approach”, where quarantine pests are cumulatively reduced to acceptable levels using independent, pre- and postharvest measures that comprise a systems that effectively mitigate the pest. Preharvest reductions in population through the study and application of chemical ecology involving insect behavior modifying chemicals can be an integral part of systems approach. This results in low pest prevalence prior to end point treatment, where pests may be effectively controlled using a less-than-Probit 9 level, low-dose treatment. In this talk, I discuss the chemical ecology of invasive quarantine pests including Drosophila suzukii and its perspective in the effective end point fumigation treatment using ethyl formate.