Lubricant oil waste contaminated with radioactive materials generated at nuclear facilities can be disposed of as industrial waste in accordance with self-disposal standards if only radioactive materials are removed. Lubricant oil used in nuclear facilities consists of oil of 75-85% and additives of 15-25%, and lubricant oil waste contains heavy metals, carbon, glycol, etc. In addition, lubricant oil waste from nuclear facilities contains metallic gamma-ray emission radionuclides including Co-60, Cs-137 and volatile beta-ray emission radionuclides such as C-14 and H-3, which are not present in lubricant oil waste from general industries and these radionuclides must be eliminated according to the Atomic Energy Act. In general industries, the wet treatment technologies such as acid-white soil treatment, ion purification, thin film distillation, high temperature pyrolysis, etc. are used as the refining technology of lubricant oil waste, but it is difficult to apply these technologies to nuclear industrial sites due to restrictions related with controlling the generation of secondary radioactive waste in sludge condition containing radionuclides of metal components, and limiting the concentration of volatile radioactive elements contained in refined oil to be below the legal threshold. In view of these characteristics, the refinement system capable of efficiently refining and treating lubricant oil waste contaminated with radioactive materials generated in nuclear facilities has been developed. The treatment process of this R&D system is as follows. First, the moisture in the radioactive lubricant oil waste pretreated through the preprocessing system is removed by the heated evaporating system, and the beta-emission radionuclides of H-3 and C-14 can be easily removed in this process. Second, the heated lubricant oil waste by the heated evaporating system is cooled through the heat exchanging system. Third, the particulate matters with gamma-ray emission radionuclides are removed through the electrostatic ionizing system. Forth, the lubricant oil waste is stored in the storage tank and the purified lubricant oil waste is discharged to the outside after sampling and checking from the upper, middle and lower positions of the lubricant oil waste stored in the storage tank. Using this R&D system, it is expected that the amount of radioactive waste can be reduced by efficiently refining and treating lubricant oil waste in the form of organic compounds contaminated with radioactive materials generated in nuclear facilities.

본 연구는 파킨슨 질환(Parkinson’s disease) 마우스 모델을 대상으로 지구성 운동과 MitoQ 섭취가 뇌의 흑질의 미토콘드리아 기능에 미치는 영향을 확인하는데 목적이 있다. 파킨슨 질환을 유도하기 위해 C57BL/6 수컷 마우스를 대상으로 복강 내 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) 25mg/kg과 흡수를 돕기 위한 probenecid 250mg/kg을 이용하여 주 2회 5주간 총 10회 투여하였다. 실험 집단은 생리식염수를 투여하는 집단(Normal Conrol (NC), n=10), MPTP 투여집단(MPTP Control (MC), n=10), MPTP 투여 + MitoQ 투여집단(MPTP + MitoQ (MQ), n=10), MPTP 투여 + 운동집단 (MPTP + Exercise (ME), n=10), MPTP 투여 + MitoQ 투여 + 운동집단(MPTP + MitoQ + Exercise (MQE), n=10) 총 5 집단으로 구성하였으며, 운동집단은 지구성 운동을 실시하였고 MitoQ집단은 점진적으로 250μmol로 늘리면서 5주간 섭취하였다. 연구결과 Rotarod-test에서 MC 집단에 비해 처치 집단은 운동 기능 저하의 개선을 보였다. 또한 MC 집단에 비해 처치 집단은 tyrosine hydroxylase의 수준의 증가와 알파시누클린(α-synuclein) 단백질 축적을 감소시켰다. 그리고 미토콘드리아 생합성에 주요조절 인자인 PGC-1α와 항산화 효소인 Catalase 발현이 MC 집단에 비해 처치 집단에서 증가해 미토콘드리아 기능을 개선했으며, 세포사멸 조절인자인 Bcl-2의 증가와 Bax의 감소를 통해 세포사멸을 완화했다. 따라서 5주 간의 지구성 운동과 MitoQ 섭취는 파킨슨 질환에서 나타나는 병리학적 특징을 완화하고 운동기능을 향상 시키는데 효과적인 것으로 나타났다.