With the rapid development of the digital economy in countries around the world, international trade has entered a new period of development. In order to effectively improve the governance capabilities of the digital economy and better adapt to the development trend of the global digital economy, countries have put their participation in various international economic and trade agreements on the important agenda. As friendly neighbors, China and South Korea have a long history of trade. In the context of the in-depth advancement of digital trade development by countries around the world, aligning with high-standard international economic and trade rules has become the focus of the development of digital trade between China and South Korea. This research starts with the aspects of business and trade facilitation, data flow and personal information protection, emerging trends and technologies, and expounds the content of DEPA, the first international digital trade agreement, and shows that joining DEPA will affect China and South Korea. The main impact of digital trade is specifically reflected in the choice of flexible digital trade participation models, the implementation of efficient and feasible digital trade system specifications, the breaking of traditional digital trade monopolies in major countries, and the provision of important opportunities for global digital trade layout. Finally, the prospects of China and South Korea after joining DEPA are prospected, pointing out continuous efforts to achieve the docking of technology and international standards, establish a more complete system-level guarantee, and strengthen industry selfdiscipline and cooperation among private entities. The above discussion aims to take the entry of DEPA as an entry point and provide a useful reference and reference for the healthy development of digital trade between China and South Korea in the future.