Three edible mushrooms; "Gumbit"(Pleurotus cornucopiae var. citrinopileatus) and Noeul"(Pleurotus salmoneostramineus) and Tricholoma spectabilis which are widely distributed in China, Japan and Korea. For the study of anti-aging activities, we were performed on adriamycin-induced cellular senescence model. Human dermal fibroblasts(HDFs) and human umbilical endothelial cells(HUVECs) treated with adriamycin for inducing aging were used for cytotoxicity and senescence-associated beta-galactosidase(SA-β-gal) activity assay.