Background: Early rehabilitation after partial meniscectomy is important to recover the balance of the vastus medialis oblique and vastus lateralis and prevent pathological problems in the lower extremities and the whole body. Objective: To compare muscle activations for patients after partial meniscectomy. Design: Dual-group Pretest-Posttest Design from the Quasi-Experimental Research. Methods: Twenty participants after partial meniscectomy were recruited and were randomly divided into a Q-setting sensorimotor training group (QSMTG) and Q-setting exercise group (QSEG). Muscle activity of the vastus medialis oblique and vastus lateralis was measured before and after intervention. Results: In the two groups, the vastus medialis oblique and vastus lateralis activations increased significantly (P<.05). The Q-setting sensorimotor training group showed more increases than the Q-setting exercise group, and there were significant differences between the groups (P<.05). The activation ratio of the vastus medialis oblique and vastus lateralis had increasingly significant differences in the Q-setting sensorimotor training group (P<.05), and there were no significant differences between the groups (P>.05). Conclusion: Q-setting exercise with sensorimotor training was a useful method that improved the balance of vastus medialis oblique (VMO) and vastus lateralis (VL) activity after meniscectomy.