In order to maximize the function and increase the compatibility of silicone hydrogel lens, this study compared and analyzed the properties of Amino modified silicone oil using mini and microemulsion technique, respectively. Optical and physical properties were evaluated by spectral transmittance, refractive index, water content, oxygen transmittance and contact angle measurements to evaluate the performance of the manufactured hydrogel lens. The spectral transmittance results revealed the copolymerization method lens showed 31 % of the visible light area, which did not satisfy the basic optical properties. However, the lens using the mini and microemulsion materials showed more than 90 % of the visible light area, satisfying the optical characteristics. In addition, all physical properties were superior to a basic hydrogel lens. The mini and microemulsion techniques effectively improved the stability and function of the ophthalmic hydrogel lens and are considered a promising ways of manufacturing an ophthalmic hydrogel contact lens with increased compatibility and stability.

Abstract Purpose : This study analyzed physical properties using 1,6-Hexanediol diacrylate (HDDA) as an additive to improve functionality of hydrogel lens such as durability. It was checked whether HDDA can be applied as a crosslinking agent in place of ethylene glycol dimethacrylate (EGDMA). Methods : Polymerization used thermal polymerization and photopolymerization methods, and HDDA was added to each polymerization method at a ratio of 1∼20%. Optical and physical characteristics of the manufactured lens were evaluated by measuring spectral transmittance, refractive index, water content, tensile strength, contact angle, and AFM. Results : Regardless of the polymerization method, the tensile strength ranged from 0.232~0.408 kgf/mm2 in thermal polymerization and from 0.146~0.429 kgf/mm2 depending on the addition ratio of HDDA. In addition, as a result of using HDDA instead of EGDMA, it was confirmed that the physical characteristics of the lens were similar to that of EGDMA, and in the case of tensile strength, HDDA was much improved. Conclusion : HDDA has been shown to be effective in improving the functionality of hydrogel lens and to improve stability and durability. In addition, it is believed that it can be used in various ways as an ophthalmic material as well as a photopolymerization crosslinking agent. Key words : Crosslinking agent, Tensile strength, 1,6-Hexanediol diacrylate, Hydrogel lens

The physical and antibacterial properties of ophthalmic lenses fabricated by copolymerization with hydrogel monomers using two types of graphene were measured, and their usability as contact lens materials was analyzed. For polymerization, silicone monomers, including SID-OH, 3-(methacryloxy)propyl tris(trimethylsiloxy)silane, and decamethylcyclopentasiloxane, were used, and N,N-dimethylacetamide, ethylene glycol dimethacrylate as a crosslinking agent, and azobisisobutyronitrile as an initiator were added. Also, graphene oxide nanoparticle (GON) and graphene nanoplate (GNP) were used as an additive, and the physical properties of the lenses fabricated after copolymerization were evaluated. The fabricated lenses satisfied the basic physical properties of general hydrogel contact lenses and showed the characteristics of lenses with high water content, and the disadvantage of very weak durability, due to low tensile strength. However, it was confirmed that the tensile strength and antibacterial properties were greatly improved by adding GON and GNP. With GON, the oxygen permeability and refractive index of the fabricated lenses were slightly improved. Therefore, it was determined that the graphene materials used in this study can be used in various ways as a contact lens material.

이 연구에서는 지표 관측 자료와 위성 자료 그리고 GWNU 단층 복사 모델을 이용하여 맑은 상태의 전천 일사 량을 계산하였으며, 전운량에 따라 관측 및 모델의 일사량 값을 비교 분석하였다. 연구 자료는 2012년 강릉원주대학교 복사 관측소의 전천 일사량, 기온, 기압, 습도, 에어로졸 등의 관측 자료와 OMI 센서의 오존전량 자료 그리고 구름의 유무 및 전운량을 판단하기 위하여 자동 전운량 장비인 Skyview 자료를 이용하였다. 전운량이 0 할인 맑은 날의 경우 관측 값과 모델 값이 0.98로 높은 상관계수를 나타내었으나 RMSE가 36.62Wm−2로 비교적 높게 나타났다. 이는 Skyview 장비가 얇은 구름이나 박무 및 연무 등의 기상상태를 판단하지 못하였기 때문이다. 흐린 날의 경우 구름의 영 향을 보정하기 위해 전운량과 두 값의 차에 대한 비율을 이용한 회귀식을 복사 모델에 적용하였으며, 장비의 오탐지를 제외한 경우 상관계수가 0.92로 높은 상관성을 보였으나 RMSE가 99.50 Wm−2으로 높은 값을 보였다. 더 정확한 분석 을 위해서는 직달 성분의 차폐 유무 및 구름 광학 두께를 포함한 다양한 구름 요소의 추가적인 분석이 요구된다. 이 연구결과는 분 또는 시간에 따른 일사량을 산출하여 일사량이 관측되지 않는 지역에서 유용하게 사용될 수 있다.

The aim of this study was to investigate the effect of uterine histotroph on embryo development and the expression of cysteine-rich protein 2 (CRP2), coatomer subunit gamma-2 (G2COP), myoglobin (MYG), vascular endothelial growth factor D (VEGFD), collagen alpha 4 chain (COL4) and galactoside 3-L-fucosyltransferase 4 (FUT4) proteins in porcine embryo during pre-implantation. Uterine histotroph (UH) was collected from uterine horn on corpus albican phase, and embryos were cultured in porcine zygote medium with UH for 168 hours. Cleavage and blastocyst formation of embryo were detected at 168 hours after in vitro fertilization. And CRP2, G2COP, MYG, VEGFD, COL4 and FUT4 proteins were observed using confocal laser microscope. In results, embryo cleavage rate was not significantly changed by UH, but blastocyst rate was significantly (P<0.05) decreased in UH-treated embryos. Moreover, CRP2, G2COP, MYG, VEGFD, COL4 and FUT4 proteins were expressed in blastomere. CRP2 in embryo was significantly overexpressed (P<0.05), but not G2COP, MYG, VEGFD, COL4 and FUT4 proteins. In summary, UH on corpus albican phase was increased CRP2 protein in embryo, and inhibited blastocyst formation in preimplantation porcine embryos, suggesting that CRP2 may play an interrupter on embryo development in pigs.