Primary CNS lymphoma (PCNSL) accounts for 1-5% of all primary brain tumors. Early and accurate diagnosis of PCNSL is crucial for proper management and is more likely if a tumor is observed on imaging. We present the PCNSL case of 77-year-old man who developed abrupt neuropsychiatric features from 5 days ago. This case suggests that clinicians should be alert on the possibility of PCNSL and apply prompt MRI evaluation, when elderly patient with chronic heavy alcohol drinking history present abrupt complex neuropsychiatric symptoms in outpatient clinic.

Primary progressive aphasia (PPA) is a progressive degenerative disorder that primarily affects language. Although the etiology of PPA has not been determined, autoimmune mechanism is known to be one possible pathophysiology. We investigate efficacy of steroid treatment in a patient diagnosed as both logopenic variant PPA and Sjögren's syndrome. After steroid treatment, her cognitive function, especially language ability showed improvement. And also, FDG-PET showed metabolic increase in the bilateral temporal lobe. However, on reassessment after stopping steroid treatment, her cognitive performance declined to pretreatment level.