In veterinary medicine, anaesthesia is fundamental for many medical acts, as complementary tests or surgical procedures. This discipline has evolved enormously in recent years, both in terms of practices as well as in terms of materials and used molecules.The aim of the present study was to compare three anaesthetic protocols, using injectable anaesthesia Ketamine/xylazine/acepromazine, ketamine/xylazine, and ketamine/xylazine /meloxicam in rabbits. Nine adult males, Neo-Zealand breed rabbits, weighing between 2.5 and 3.5 Kg were randomly divided into three groups, housed indoor to accommodate the place of experiments to evaluate their effects on risk factors associated with peri-anaesthetic mortality, along with gastrointestinal complications, in order to establish a suitable anaesthetic protocol, coupled with continuous monitoring of the anaesthetized animal. The association of acepromazine, xylazine, and ketamine, which give a deep myorelaxation and remarkable analgesia, obtained the anaesthesia. Fixed products do not lead to any myorelaxation of the mandibular muscles. The addition of a non-steroidal anti-inflammatory drug increased the effect of the peri-anaesthetic analgesia. The protocol using acepromazine, xylazine, and ketamine is the best schema for the potentiated general anaesthesia in rabbit, because of its insignificant effect on the intestinal motility.