This case report describes the successful management of a recurrent eyelid tumor in a 10-year-old, neutered male Labrador Retriever using surgical debulking combined with cryotherapy. The mass was located on the margin of the left upper eyelid, near the medial canthus, and had recurred two years after a previous excision. Due to the patient's history of nephrectomy and the owner's concerns regarding general anesthesia, the procedure was performed under light sedation. After debulking of the tumor, two freeze-thaw cycles (25-second freeze, 40-second thaw) were applied to the remaining tumor bed. Histopathological examination confirmed a meibomian gland epithelioma. The surgical site healed well with only mild depigmentation, and no recurrence was observed during the 8-month follow-up period. This combined approach represents an effective, minimally invasive option for treating canine eyelid tumors, particularly in high-risk patients.

A 13-year-old spayed female Pomeranian presented with a mass in the left eye. Slit-lamp examination, ultrasound, and CT revealed an iris-derived mass extending to the sclera, suspicious for scleral invasion. A partial iris biopsy was performed. Histopathology confirmed an anterior uveal melanocytoma with no malignant features. Despite imaging findings suggesting invasion, the patient was managed conservatively with topical anti-inflammatories post-biopsy. Over a 7-month follow-up period, the lesion remained stable, and vision was preserved without complications. This case highlights the importance of histopathology for accurate diagnosis and management of canine uveal melanocytic neoplasms, as conservative management can be a viable option.