간행물
예방수의학회지 KCI 등재 Journal of Preventive Veterinary Medicine
- 발행기관 한국예방수의학회(구 한국수의공중보건학회)
- 자료유형 학술지
- 간기 계간
- ISSN 2287-7991 (Print)2287-8009 (Online)
- 수록기간 1978 ~ 2025
- 주제분류 의약학 > 수의학 의약학 분류의 다른 간행물
- 십진분류KDC 528DDC 636
권호리스트/논문검색
제49권 4호 (2025년 12월) 19건
1.
2025.12
구독 인증기관 무료, 개인회원 유료
This study evaluated the insect growth regulator pyriproxyfen (PPF) for its inhibitory effects on the adult emergence of fly (Musca domestica) and mosquito (Culex pipiens) larvae. Laboratory bioassays with a product containing 0.5% PPF were conducted using diet incorporation for fly larvae and water immersion for mosquito larvae at concentrations of 80, 160, and 320 mg/kg (flies) or mg/L (mosquitoes). PPF treatment reduced adult emergence in a dose-dependent manner. At 160 mg/kg (or mg/L), corrected adult emergence inhibition rates exceeded 80%, which meets regulatory thresholds for efficacy. Residual activity tests demonstrated sustained effects, with fly larvae showing 70% inhibition and mosquito larvae complete suppression (100%) at 45 days post-treatment. These findings confirm that PPF effectively disrupts metamorphosis of both species, with particularly strong and prolonged effects against mosquitoes.
4,000원
2.
2025.12
구독 인증기관 무료, 개인회원 유료
Veterinary drugs can remain as residues in animal-derived food products, and therefore, many countries conduct residue monitoring programs for imported livestock products. However, because the types and authorizations of veterinary drugs vary among countries, it is necessary for importing nations to establish residue monitoring systems tailored to their specific circumstances. This study aimed to develop an algorithm to quantitatively evaluate and score the risk of veterinary drug residues that may be present in imported livestock products, thereby enabling risk-based prioritization. The overall risk score was calculated as the product of exposure and toxicity factors. To minimize uncertainty, the algorithm utilized objective and accessible data obtained from both domestic and international sources. The exposure factor was determined using the number of residue violations and the estimated exposure value, which was calculated based on withdrawal periods and maximum residue limits (MRLs). The toxicity factor was evaluated using the acceptable daily intake (ADI) and the regulatory importance of the substances. The regulatory importance was classified according to the antimicrobial resistance (AMR) ranking criteria of the World Health Organization (WHO) and the World Organisation for Animal Health (WOAH), while substances not covered by these classifications were ranked based on their impact on the human intestinal microbiota. According to the results of residue violation grading by country and substance, when focusing on meat (excluding dairy products), the United States had the highest number of Grade 5 substances (seven), followed by Canada, Brazil, Mexico, Spain, Uruguay, and Chile, which each contained Grade 5 substances. In domestic livestock products, 14 substances—including cefazolin and amoxicillin—were classified as Grade 5 in beef, eight substances—including amoxicillin and cefquinome—as Grade 5 in pork, and bifenthrin as a Grade 5 substance in poultry. Based on MRL grading, phenylbutazone, norgestomet, and flumethasone were classified as Grade 5 in beef; phenylbutazone, altrenogest, and flumethasone in pork; and phenylbutazone and dexamethasone in poultry. For ADI-based grading, oleandomycin, cefadroxil, avilamycin, norgestomet, and dexamethasone were identified as Grade 5 substances. Withdrawal period grading indicated that gentamicin was categorized as Grade 5 across all livestock types, including cattle, swine, poultry, and milk. In terms of regulatory importance, danofloxacin, ceftiofur, spiramycin, erythromycin, and enrofloxacin were classified as Grade 5 substances. The risk-prioritization algorithm developed in this study identified five substances—ampicillin, closantel, phenylbutazone, ractopamine, and zeranol—as having the highest possible risk score (25 points) in imported beef. This algorithm enables risk-based prioritization using the results of national residue monitoring programs conducted by exporting countries, thereby allowing importers to establish inspection priorities tailored to their own contexts. Consequently, the developed algorithm can be effectively utilized to identify high-risk veterinary drugs by exporting country and livestock type, supporting the establishment of more efficient monitoring plans for imported livestock products.
4,600원
3.
2025.12
구독 인증기관 무료, 개인회원 유료
The importance of the immune system in the pathogenesis of periodontitis is being emphasized. To investigate the effects of different immune statuses on the progression of periodontitis, we induced periodontitis in neutrophil-deficient, lymphocytedeficient, and dual neutrophil- and lymphocyte-deficient mice. The groups included BALB/c mice (Con-lym+/neu+), periodontitisinduced BALB/c and SCID mice (Peri-lym+/neu+ and Peri-lym–/neu+), and periodontitis-induced BALB/c and SCID mice treated with anti-Ly6G antibody (Peri-lym+/neu– and Peri-lym–/neu–). Periodontitis was induced by ligation of the mandibular first molar. Mice were sacrificed on days 0 (D0), 3 (D3), and 7 (D7) after ligation, and blood and periodontal tissue were analyzed. On D3, the AB area in the Peri-lym–/neu+ group was larger than in the Peri-lym+/neu+ group. The osteoclast on D3 was lower in the Peri-lym+/neu– group compared to the Peri-lym+/neu+ group. On D7, Ly6G+ cells were lower in both blood and periodontal tissue in the Peri-lym+/neu– group compared to the Peri-lym+/neu+ group, whereas CD3+ cell counts were higher only in periodontal tissue. In the Peri-lym–/neu– group, Ly6G+ cells were lower in both blood and periodontal tissue than in the Peri-lym–/ neu+ group, whereas CD3+ cells were higher in blood only. These results suggest that lymphocyte depletion delays AB loss and neutrophil depletion influences osteoclast formation at the early stage of periodontitis. In the late stage of periodontitis, lymphocyte depletion does not increase lymphocyte infiltration into periodontal tissue, even with neutrophil depletion. Collectively, different immune states may influence distinct stages of periodontitis progression.
4,000원
4.
2025.12
구독 인증기관 무료, 개인회원 유료
Goun Park, Chul Un Chung, Taeung Jung, Yonghak Ahn, Kiok Ahn, Kyongman An, Dahyun Hwang, Dongju Jung, Hyun-Seok Jin, Sang-Hee Jeong, Chunghyun Kim
This study establishes standardized necropsy protocols and describes the anatomical characteristics of greater horseshoe bats (Rhinolophusferrumequinum), with sex-based comparisons and interspecific analysis. Six deceased bats (4 males, 2 females) were collected from South Korea between May and August 2025. Comprehensive necropsies were performed following Biosafety Level 2 protocols. Body weight showed no significant sexual dimorphism (females: 18.23 ± 1.26 g; males: 17.22 ± 3.42 g; p = 0.720). Of 13 morphometric parameters, only the second digit length (D2) was significantly longer in males (40.00 ± 0.82 mm) than females (36.50 ± 2.12 mm; p = 0.034). Internal anatomy revealed flight adaptations, including pectoral muscles comprising >80% of muscle mass, asymmetric two-lobed lungs, and a 170 mm intestinal tract where the stomach and cecum were indistinct. Males exhibited symmetrical, white, round testes (5 mm diameter) located 15 mm from the abdominal cavity. Mild hepatic lipidosis was observed in 33% of specimens, but no parasites or wing lesions were found. Comparative analysis with Miniopterusfuliginosus from Jeju Island highlighted interspecific differences in body size and morphology. This study provides essential baseline data for the health monitoring and conservation management of Korean bat populations.
4,000원
5.
2025.12
구독 인증기관 무료, 개인회원 유료
Lactobacillus johnsonii JERA01-supplemented feed additive (Lj-A) was produced by fermenting dried porcine blood with Lactobacillus johnsonii (Lj). Lj-A has highly digestible nutrients, bioactive peptides, and probiotic effects. To assess the immunomodulatory potential of Lj-A, it was tested on splenocytes of C57BL/6 mouse. Lj-A was treated on splenocytes in a range of concentration, 0-100 μg/ml. The metabolic activity of splenocytes was enhanced by Lj-A, as shown in MTT assay. Also, some splenocyte clusters were observed under a bright-field microscope on the wells treated with Lj-A. The splenocyte clusters indicated that the cells were activated and proliferating in response to Lj-A. These findings suggest that Lj-A stimulates splenocytes to promote immune cell activation, as evidenced by increased tumor necrosis factor-alpha and interleukin-12 production, thereby enhancing immunological defense functions. In vitro treatment of splenocytes with Lj-A increased the proportions of T cells, B cells, and CD25+ cells. In vivo, immune cell activity was evaluated in C57BL/6 mice orally administered with Lj-A at a dose of 100 mg/day. The proportion of dendritic cells in peritoneal cells was increased along with elevated CD54+ expression. Additionally, the proportions of B cells, CD25+ cells in Peyer’s patch cells increased as well. These results suggest that Lj-A may contribute to the enhancement of immune function and the maintenance of long-term health in animals.
4,000원
6.
2025.12
구독 인증기관 무료, 개인회원 유료
The objectives of this retrospective cohort study were to investigate the Acute Patient Physiologic and Laboratory Evaluation (APPLE) score and its components as prognostic markers in dogs with acute pancreatitis. Forty-seven dogs were diagnosed with acute pancreatitis based on satisfying two criteria: the presence of two acute clinical signs (vomiting, anorexia, abdominal pain, or lethargy) and confirmation via specific canine pancreatic lipase (cPL) testing. cPL concentration within the intermediate range supported by compatible ultrasonographic evidence. The dogs were categorized into survival and non-survival groups. The APPLE score components (mentation, respiratory rate, fluid score, SpO₂, WBC, creatinine, albumin, total bilirubin, and lactate) were assessed within 24 hours of admission. Statistical comparisons between the groups showed that the non-surviving dogs had significantly higher APPLE scores (39.36 ± 4.41) compared to the survivors (25.67 ± 9.63, p < 0.01). The predictive ability of the APPLE score for distinguishing the survival group from the non-survival group was excellent, with an Area Under the Curve (AUC) of 0.900. Using the optimal cut-off value, a sensitivity of 1.000 (100.0%) and a specificity of 0.750 (75.0%) were achieved. There were also differences in mentation score, fluid score, SpO₂, creatinine, lactate, and cPL levels between the two groups, indicating poorer prognoses in the non-survivor group. In conclusion, the APPLE score serves as a valuable tool for predicting outcomes in dogs suffering from acute pancreatitis. Its use can help clinicians identify patients at risk, enhance risk assessment, inform treatment decisions, and improve communication with dog owners regarding prognosis.
4,000원
7.
2025.12
구독 인증기관 무료, 개인회원 유료
Seong Eun Cho, Tran Xuan Ngoc Huy, Trang Thi Nguyen, Ched Nicole Turbela Aguilar, Eoin Quiatchon Lajara, Il-Hwa Hong, Won-Gi Min, Hu-Jang Lee, Ji-Hyun Yeom, Suk Kim
It is challenging to treat canine brucellosis due to the immune evading and stealthy characteristic of the causative bacteria, Brucella (B.) canis. Gold nanoparticle aptamer (AuNP-Apt) conjugated antimicrobial peptide (AMP) is a promising alternative to antibiotics for various bacterial infections. However, the toxicity of AuNP-Apt has been variable throughout research, and the in vivo toxic mechanism has not been fully elucidated. This study evaluated the therapeutic potential against B. canis, and the toxicity of AuNP-Apt conjugated antimicrobial peptide, RW-BP100 (AuNP-AptHis-RW-BP100His), in a mouse model. Intravenous (IV) treatment with AuNP-AptHis-RW-BP100His reduced the bacteria burden and histopathologic lesions. The IV treatment also induced CD4+ T cell differentiation and modulated serum cytokine levels. However, high-dose AuNP-Apt was lethal, resulting in tissue accumulation and vessel embolism. Therefore, AuNP-AptHis-RW-BP100His is a promising therapeutic agent for B. canis treatment, but due to its toxicity, further studies are needed for its utilization in clinical practice.
4,000원
8.
2025.12
구독 인증기관 무료, 개인회원 유료
Canine cognitive dysfunction (CCD) is a progressive neurodegenerative disorder in aging dogs, sharing significant pathological similarities with human Alzheimer's disease (AD), such as amyloid-beta deposition and neuroinflammation. Yukgunja-tang (YGJ), a traditional herbal formula, has been reported to alleviate psychological symptoms via the gut-brain axis. However, its molecular mechanisms in treating CCD remain unclear. This study was about a network pharmacology approach to elucidate the multi-component, multi-target mechanisms of YGJ against CCD. Active compounds and relates of YGJ drugs and CCD targets were retrieved from the TCMSP (Traditional Chinese Medicine Systems Pharmacology database and analysis platform) and GeneCards databases, respectively. We identified 148 common targets between YGJ drugs and CCD symptom. A protein-protein interaction (PPI) network analysis revealed key hub genes, including TNF (tumor necrosis factor), IL1B (interleukin 1 beta), AKT1 (Ak strain transforming 1), TP53 (tumor protein 53), and IL10 (interleukin 10), which are predominantly involved in inflammation and cell survival. KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analysis indicated that these targets are significantly enriched in the age-rage signaling pathway and cancer pathways, suggesting mechanisms involving the regulation of neuroinflammation and oxidative stress. These findings hypothesize that YGJ exerts therapeutic effects on CCD through a holistic approach: inhibiting neuroinflammation, modulating age-related cellular stress, and regulating cell signaling cascades. This study provides a scientific basis for YGJ as a potential integrative treatment for improving the quality of life in dogs with CCD.
4,000원
9.
2025.12
구독 인증기관 무료, 개인회원 유료
Enterotoxigenic Escherichia coli (ETEC) and Clostridium perfringens are key pathogens responsible for neonatal and post-weaning diarrhea, causing notable morbidity, mortality, and economic loss worldwide. However, nationwide data on bacterial pathogens causing piglet diarrhea in Korea remain limited. This study aimed to determine the prevalence and distribution of E. coli fimbrial and toxin genes, C. perfringens, and Clostridioides difficile in diarrheic piglets in Korea (2023-2024). Overall, 1,339 fecal samples were collected from diarrheic piglets across Korean pig farms. Species-specific virulence genes were detected using real-time polymerase chain reaction assay targeting major fimbrial and toxin factors of E. coli, C. perfringens (CPA), and C. difficile (TcdA/TcdB). Prevalence was compared across years and seasons. Among E. coli fimbrial factors, F18 (17.0%), F4 (7.4%), and F17 (4.7%) were common, whereas F5, F6, and F41 were rare (<3%). STb (30.1%) and STa (21.1%) were common, and Stx2e prevalence increased from 6.8% to 13.4% (p < 0.001). LT was detected in 9.0% of cases; C. perfringens in 22.3% of cases, increasing from 17.9% to 27.4% (p < 0.001); and C. difficile in 7.7% of cases. Several pathogens showed quarterly variations, with F4 and STa peaking in Q1 (January-March), STb in Q3 (July-September), and C. perfringens showing higher detection rates in Q1 and Q4 (October-December). ETEC-associated fimbrial and toxin genes, particularly F18/F4 and STa/STb, remained the most frequently detected among diarrheic piglets in Korea, with Stx2e and C. perfringens also playing important roles. These findings highlight the multifactorial nature of piglet diarrhea and the need for continuous nationwide surveillance and integrated prevention strategies.
4,000원
10.
2025.12
구독 인증기관 무료, 개인회원 유료
Mitochondrial genomes have been documented for select subspecies of Rhinolophus ferrumequinum (the greater horseshoe bat); however, a lack of comprehensive population-level sequences continues to limit our understanding of its complex phylogeographic history. This study reports the complete mitochondrial genome of the R. ferrumequinum sampled from South Korea and sequenced at Hoseo University. The circular mitogenome is 16,795 bp in length and comprises the typical 37 mitochondrial genes (13 protein-coding genes, 22 tRNA genes, two rRNA genes) and one non-coding control region, showing an overall base composition of GC content 42.74%. Phylogenetic analysis based on mitochondrial protein‑coding genes places this genome in R. ferrumequinum providing a new genomic resource for population genetics of horseshoe bats in East Asia.
3,000원
11.
2025.12
구독 인증기관 무료, 개인회원 유료
Zoonotic diseases transmitted through interconnected networks of humans, animals, and the environment are intensifying global public health and biosecurity threats under the One Health paradigm. Conventional diagnostic methods— including microbial culture, serological testing, and PCR-based molecular assays—are accurate but time-consuming, equipment-dependent, and difficult to implement in field settings. In this context, CRISPR-based nucleic acid diagnostics have emerged as an innovative tool that enables rapid, sensitive, and specific detection with minimal instrumentation. This review provides a comprehensive overview of CRISPR systems and their diagnostic mechanisms, with a focus on point-of-care detection of zoonotic pathogens such as SARS-CoV-2, Salmonella spp., Listeria monocytogenes, Bacillus anthracis, Brucella spp., Mpox virus, and avian influenza virus. It also discusses field-deployable technologies, including digital CRISPR assays, one-tube platforms, electrochemical biosensors, and portable diagnostic systems aligned with WHO ASSURD criteria. In addition, the review examines practical considerations for applying CRISPR-based diagnostics in veterinary and food safety settings, including reagent stabilization, matrix compatibility, multiplex detection, and integration with data systems. Collectively, these advances position CRISPR diagnostics as a cornerstone of precision disease surveillance and early intervention within the One Health framework. This innovation heralds a new era of intelligent preventive veterinary medicine that aims to break zoonotic transmission cycles and ensure sustainable biosecurity.
4,000원
12.
2025.12
구독 인증기관 무료, 개인회원 유료
This paper reviews the genetic evolution and zoonotic potential of Alphacoronavirus suis (CCoV and FCoV), highlighting the emergence of highly virulent, recombinant variants. CCoV evolved from enteric strain into pantropic variants (e.g., CB/05, CCoV-2c, CCoV10/22) and gaining enhanced virulence, systemic dissemination, and severe clinical signs including lymphopenia. FCoV saw the emergence of the highly virulent FCoV-23 in 2023, which exhibits near-universal progression to FIP, increased neurological involvement, and exceptional direct cat-to-cat transmission efficiency, a major deviation from classical FCoV. The detection of CCoV-HuPn-2018 in humans and ongoing recombination in wildlife confirm the zoonotic potential. Alphacoronavirus suis was historically confined to the veterinary field, and attention to this group, apart from FCoV causing Feline Infectious Peritonitis (FIP), was relatively limited. However, recent emergence of variants exhibiting altered host tropism and direct transmission capability, coupled with the detection of CCoV in humans, necessitates integrated surveillance for pandemic preparedness against these rapidly evolving alphacoronaviruses.
4,000원
13.
2025.12
구독 인증기관 무료, 개인회원 유료
Uterine adenocarcinoma is the most common neoplasm in companion rabbits. A 5-year-old intact female Lionhead rabbit was presented with a 5-day history of hematuria, hyporexia, and decreased fecal output and pellet size. Thoracic and abdominal radiography, ultrasonography, and hematologic analyses revealed enlarged uterine masses in the caudoventral abdomen. An ovariohysterectomy was performed, and histopathology confirmed uterine adenocarcinoma. The rabbit recovered postoperatively and has remained clinically well 14 months after surgery. This case report describes the successful surgical management of uterine adenocarcinoma in a companion rabbit by ovariohysterectomy.
3,000원
14.
2025.12
구독 인증기관 무료, 개인회원 유료
Traumatic urethral rupture is uncommon in cats but may occur secondary to high energy trauma and can cause severe systemic compromise. An 8-month-old neutered male cat presented after trauma by hit-by-car, and retrograde urethrography confirmed a pelvic urethral rupture. Despite conservative management, urethral stricture subsequently developed. Surgical correction was performed by resection of the stenotic segment and urethral anastomosis via a pubic osteotomy approach. The cat recovered normal urination without complications, and no recurrence was observed during one year of follow-up. This case demonstrates successful surgical repair of post-traumatic urethral rupture and stricture in a cat using a pelvic osteotomy approach.
4,000원
15.
2025.12
구독 인증기관 무료, 개인회원 유료
A 13-year-old spayed female Pomeranian presented with a mass in the left eye. Slit-lamp examination, ultrasound, and CT revealed an iris-derived mass extending to the sclera, suspicious for scleral invasion. A partial iris biopsy was performed. Histopathology confirmed an anterior uveal melanocytoma with no malignant features. Despite imaging findings suggesting invasion, the patient was managed conservatively with topical anti-inflammatories post-biopsy. Over a 7-month follow-up period, the lesion remained stable, and vision was preserved without complications. This case highlights the importance of histopathology for accurate diagnosis and management of canine uveal melanocytic neoplasms, as conservative management can be a viable option.
3,000원
16.
2025.12
구독 인증기관 무료, 개인회원 유료
Urethral obstruction in male cats, commonly caused by urolithiasis or FLUTD, can be life-threatening. Modified perineal urethrostomy (MPU), connecting the proximal urethra to the preputial mucosa, was performed in three male cats. Two cases with urolithiasis underwent concurrent cystotomy, and one FLUTD case received MPU alone. Two cats recovered uneventfully, while one developed re-obstruction from urinary sludge requiring revision. MPU achieved stable urinary patency and good cosmetic results in most cases, suggesting it as an effective alternative to conventional PU; however, recurrence associated with inflammatory or metabolic causes in FLUTD indicates the need for careful postoperative medical management.
3,000원
17.
2025.12
구독 인증기관 무료, 개인회원 유료
A 7-year-old, 3.55 kg neutered male Pomeranian presented with progressive paraparesis and axial spinal pain despite three years of conservative treatment. Computed tomography (CT) revealed bony hyperplasia at T6-T7 with focal canal narrowing (Cobb angle, 39.29°), and magnetic resonance imaging (MRI) confirmed severe spinal cord compression at T7. Based on these findings, a dorsal laminectomy at T6-T7 was performed for decompression. The neurological status remained grade 3 at 7 days after surgery, and improved to grade 2 by 28 days after surgery. At four months after surgery, the patient regained independent ambulation, although proprioceptive ataxia and urinary retention persisted. This case suggests that timely focal decompression without stabilization can result neurological recovery in small-breed dogs with congenital vertebral body malformation (CVBM)-associated spinal cord compression.
4,000원
18.
2025.12
구독 인증기관 무료, 개인회원 유료
This case report describes the successful management of a recurrent eyelid tumor in a 10-year-old, neutered male Labrador Retriever using surgical debulking combined with cryotherapy. The mass was located on the margin of the left upper eyelid, near the medial canthus, and had recurred two years after a previous excision. Due to the patient's history of nephrectomy and the owner's concerns regarding general anesthesia, the procedure was performed under light sedation. After debulking of the tumor, two freeze-thaw cycles (25-second freeze, 40-second thaw) were applied to the remaining tumor bed. Histopathological examination confirmed a meibomian gland epithelioma. The surgical site healed well with only mild depigmentation, and no recurrence was observed during the 8-month follow-up period. This combined approach represents an effective, minimally invasive option for treating canine eyelid tumors, particularly in high-risk patients.
3,000원
19.
2025.12
구독 인증기관 무료, 개인회원 유료
Tae-seok Noh, Geon-Ung Byun, Jun-ho Koo, Jong-mu An, Sang-won Yoo, Young-gyu Lee, Sin-Yeoung Park, Yoon-Ho Roh, Chang-Hwan Moon, Dongbin Lee
Nasopharyngeal stenosis (NPS) is an uncommon but potentially life-threatening condition in cats, capable of causing complete upper airway obstruction in severe cases. Carbon dioxide (CO₂) laser staphylectomy provides precise tissue ablation with minimal collateral thermal injury; however, restenosis could occur when used as a sole treatment modality. Balloon dilation can temporarily restore luminal patency, yet recurrence rates remain high when performed alone. This report describes an 8-month-old Korean Shorthair cat with complete nasopharyngeal stenosis that underwent CO₂ laser ablation as an initial intervention, followed by rapid restenosis within three days. A second procedure combining CO₂ laser ablation with endoscopic balloon dilation achieved short-term maintenance of nasopharyngeal patency. These findings suggest that, in cases of complete stenosis with a high risk of recurrence, a multimodal approach may be more effective than single-modality treatment.
3,000원
