This paper reviews the genetic evolution and zoonotic potential of Alphacoronavirus suis (CCoV and FCoV), highlighting the emergence of highly virulent, recombinant variants. CCoV evolved from enteric strain into pantropic variants (e.g., CB/05, CCoV-2c, CCoV10/22) and gaining enhanced virulence, systemic dissemination, and severe clinical signs including lymphopenia. FCoV saw the emergence of the highly virulent FCoV-23 in 2023, which exhibits near-universal progression to FIP, increased neurological involvement, and exceptional direct cat-to-cat transmission efficiency, a major deviation from classical FCoV. The detection of CCoV-HuPn-2018 in humans and ongoing recombination in wildlife confirm the zoonotic potential. Alphacoronavirus suis was historically confined to the veterinary field, and attention to this group, apart from FCoV causing Feline Infectious Peritonitis (FIP), was relatively limited. However, recent emergence of variants exhibiting altered host tropism and direct transmission capability, coupled with the detection of CCoV in humans, necessitates integrated surveillance for pandemic preparedness against these rapidly evolving alphacoronaviruses.

Abstract
INTRODUCTION
GENETIC EVOLUTION OF Alphacoronavirus suisIN CATS AND DOGS
    Canine coronavirus (CCoV)
    Feline coronavirus (FCoV)
CLINICAL MANIFESTATION OF Alphacoronavirus suisINFECTIONS IN CATS AND DOGS
    Typical infections with CCoV and FCoV
    Pantropic CCoV infection and the sever clinical signsfrom recent recombinants
    Direct transmissions of feline infectious peritonitis in2023
ZOONOTIC CONCERNS OF Alphacoronavirus suis
CONCLUSION
REFERENCES

• Hyoungjoon Moon(Department of Animail Health and Welfare, College of Healthcare & Biotechnology, Semyung University, Jecheon 27136, Korea) Corresponding author