간행물
예방수의학회지 KCI 등재 Journal of Preventive Veterinary Medicine
- 발행기관 한국예방수의학회(구 한국수의공중보건학회)
- 자료유형 학술지
- 간기 계간
- ISSN 2287-7991 (Print)2287-8009 (Online)
- 수록기간 1978 ~ 2024
- 주제분류 의약학 > 수의학 의약학 분류의 다른 간행물
- 십진분류KDC 528DDC 636
권호리스트/논문검색
제48권 1호 (2024년 3월) 10건
1.
2024.03
구독 인증기관 무료, 개인회원 유료
Ischemic stroke is caused by a blockage of the cerebral artery, which leads to a severe neurological disorder. Chlorogenic acid is a phenolic acid found mainly in plants such as coffee beans, eggplants, and carrots. It exerts a neuroprotective effect against cerebral ischemic damage. Bcl-2 family protein is a representative apoptosis regulatory protein. Bcl-2 and Bcl-xL act as apoptosis inhibitors, while Bax and Bad act as apoptosis inducers.The interaction of Bcl-2 family protein plays an important role in determining cell fate. The aim of this study was to investigate whether chlorogenic acid modulates the interaction of Bcl-2 family proteins during ischemic injury. Middle cerebral artery occlusion (MCAO) surgery was performed to induce cerebral ischemia. Chlorogenic acid (30 mg/kg) or phosphate buffered saline was intraperitoneally injected to adult male rats 2 h after MCAO surgery. Neurobehavioral tests were performed to confirm the neuroprotective effect of chlorogenic acid 24 h after MCAO injury, and immunoprecipitation analysis was performed to investigate the interaction of Bcl-2 family protein. MCAO damage showed signs of severe neurological disorders, while chlorogenic acid improved these disorders. Results of immunoprecipitation analysis were as follows. Interaction between Bax and Bcl-2 or Bcl-xL was decreased in MCAO injury, chlorogenic acid prevents these decreases. In contrast to Bax, Interaction between Bad and Bcl-2 or Bcl-xL was increased in MCAO injury, chlorogenic acid prevents these increases. Furthermore, chlorogenic acid attenuated MCAO-induced increase of capase-9. In conclusion, our findings demonstrate that chlorogenic acid exerts a neuroprotective effect against cerebral ischemic injury by modulating interaction of Bcl-2 family proteins.
4,000원
2.
2024.03
구독 인증기관 무료, 개인회원 유료
Cerebrovascular disease (CVD) refers to a condition wherein the normal functioning of the brain is impaired, resulting in either temporary or permanent damage. The causes of CVD include both hemorrhagic and ischemic events. A cerebrovascular accident (CVA) refers to a condition that occurs acutely. A CVA typically involves a sudden blockage of blood supply to the brain or the rupture of blood vessels, causing damage to brain tissue. This results in impairment of crucial brain functions and can manifest in various neurological signs. This study investigated characteristics of the signalment, clinical symptoms, lesion locations, and prevalence of CVA diagnosed using a 3.0T MRI in dogs. The breeds included 5 Maltese and one each of Poodle, Pomeranian, Chihuahua, Shih-tzu, and Yorkshire terrier. There was one neutered male, five intact males, two spayed females, and two intact females. The median age and weight were 7.5 years and 3.39 kg, respectively. Clinical signs included gait abnormality in five dogs, and four dogs exhibited seizures. Additionally, there were cases of head tilt or turn (n=3) and nystagmus (n=1). The most frequently affected region was the cerebrum (n=7), followed by the cerebellum (n=3), brainstem (n=2), and thalamus (n=1). Three cases exhibited multiple lesions among these regions. In this study using a 3.0T MRI scanner, the prevalence rate was 4.39%, which was higher than that reported in previous studies.
4,000원
3.
2024.03
구독 인증기관 무료, 개인회원 유료
GN01 is a new antiviral medicine acting against Korean Sacbrood virus (KSBV) of honeybees. It contains 5 mg/mL of active ingredient, double stranded RNAs(dsRNA), that homologous to KSBV ribonucleic acid coding coat protein (VP1) of virus and inducing RNA interference (RNAi). RNA medicine is generally recognized as safe for rapid breakage by intrinsic ribonuclease and limited absorption from gastrointestinal tract. However, there were no data of repeat-dose toxicity in laboratory animals for dsRNA targeting SBV. This study was performed to investigate toxicity of GN01 in SD rats after weekly oral dosing for 28 days and to determine its no-observed-adverse-effect-level (NOAEL). Male and female SD rats were orally administered with GN01 at 0, 25, 50 and 100 mg/kg bw/day of dsRNA once per week for 28 days (total 5 administrations). The highest dose 100 mg/kg bw/day was determined based on the maximum volume injectable (20 mL/kg bw) via gavage. During treatment period, clinical signs, functional and sensory responses, body weights, food and water consumption, ophthalmological findings and urinalysis were investigated. After treatment period, hematological and clinical biochemistry tests and examination of necropsy findings, organ weights and histopathological lesions were performed. There were no significant differences between all test groups and vehicle control group in all measured parameters. Therefore, the NOAEL of GN01 was determined 100 mg/kg bw/day, the highest dose administered. In conclusion, repeated oral administration of GN01, a dsRNA medicinal product, is safe even at the maximum available dose in rats.
4,900원
4.
2024.03
구독 인증기관 무료, 개인회원 유료
Swine influenza is a respiratory infectious disease in pigs caused by Orthomyxoviridae influenza virus A. As a multihost pathogen, the virus can infect humans, birds, and pigs and has pandemic potential due to rapid mutation rate. This study investigated the seroprevalence of influenza A antibodies in pigs in Chungbuk Province to overview its temporal and spatial distribution. From March to November 2021, blood samples collected for swine fever and foot-and-mouth disease antibody tests from swine farms located in Cheongju, Jincheon, Jeungpyeong, and Goesan within the jurisdiction of the Chungbuk Animal Health Laboratory were used. Blood samples from both sows and growing pigs were collected. Additionally, three farms participating in the Expendable Disease Guidance Support Project were chosen to investigate the seroprevalence status by parity of sows and age of piglets. A total of 468 sows and 1,519 growing-finishing pigs were employed in this study. The results showed that Jincheon had the highest seropositivity rate, suggesting that more effort should be made in biosecurity to prevent mechanical transmission, given the close proximity of farms. The analysis of antibody levels in farms targeted by the Expendable Disease Guidance Support Project could suggest that once the virus enters a farm, it spreads throughout the entire pig population regardless of age. Farms that were positive in the first half of the year remained positive in 86% of cases in the second half, suggesting continuous infection within the farm unless depopulation or all-in-all-out practices are implemented. Moreover, 67% of farms that were negative in the first half remained negative in the second half, and farms managed by the same person showed identical antibody change patterns, indicating that the swine influenza virus can be transmitted by humans or vehicles. The results highlight the need for further analysis of biosecurity systems and geographical risk factors.
3,000원
5.
2024.03
구독 인증기관 무료, 개인회원 유료
In Korea, twenty-nine types of microbial pesticides and thirty-two types of naturally occurring materials and chemicals are exempt from MRL (maximum residue level), and fifty types of active ingredients of pesticides are exempt from establishing the acceptable daily intake (ADI) during the pesticide registration process. Out of these materials, twenty-nine types of microbial pesticides and thirty-two types of naturally occurring materials and chemicals are exempt from MRL. Twenty-seven microorganisms and fifteen chemicals are exempt from both ADI and MRL. The European Union exempts the MRL for 148 active pesticide ingredients, and CODEX suggested sixty-three substances as exempt substances from setting the MRL. In Japan, sixty-five types of pesticide components were exempted from MRL. MRL-exempted substances differed depending on the referenced agency, which is presumed to be due to differences in the types of pesticides approved and the approved usage methods in each country. In most countries, MRL exemptions for pesticides are based on toxicity and exposure assessments, and these substances are composed of substances that have a very low risk to the human body or remain in food and are not exposed to the human body and MRLs are exempted based on GAP (good agricultural practice) approved during the licensing process. By referring to the CODEX and the European Union's MRL exemption guidelines, a guideline for evaluating pesticide safety was prepared to determine it as an MRL-exempt substance when setting standards for pesticide residue in Korea. Conclusively, most regulatory agencies decide whether to exempt pesticides from MRL by considering GAP and indications for use during the registration process, and criteria for evaluating exemptions include risk factors, possibility of human exposure and management options.
4,000원
6.
2024.03
구독 인증기관 무료, 개인회원 유료
This study examined the relationship between Body mass index (BMI) classification and the occurrence of dyslipidemia using 3 years of health examination data from a university hospital in Changwon, and seeked to find other factors that affect dyslipidemia. Multivariate logistic regression analysis investigated the most common risk factors for developing dyslipidemia and used Kaplan-Meier survival curves to predict the probability of developing dyslipidemia according to BMI class. We then analyzed the effects of metabolic indicators such as smoking habits, alcohol consumption, blood pressure, glucose, hemoglobin A1c (HbA1c), and insulin. The Type I error rate was controlled through Bonferroni correction for multiple comparisons to extract reliable statistical data. in the present study, these results showed that the probability of developing dyslipidemia was high in the obese group, and confirmed that lifestyle habits such as smoking and drinking were highly correlated with the occurrence of dyslipidemia. Therefore, we suggest that dyslipidemia management and prevention strategies require public health policies that comprehensively manage lifestyle factors such as gender and weight management, smoking cessation, and drinking habits.
4,000원
7.
2024.03
구독 인증기관 무료, 개인회원 유료
In this study, we evaluated wound healing following the use of 3% topical povidone ointment in dogs with minor wounds and evaluated it as a new wound treatment applicable to veterinary medicine. Twenty-six dogs that had suffered minor wounds such as abrasions, punctures, and incised wound within 8 hours were recruited, and all treatments were performed with the consent of their owners. Vitality, behavioral symptoms, and dermal symptoms due to wounds were evaluated between the povidone ointment group (n=18) and the control group (chlorhexidine group, n=8). As a result of evaluating changes in vitality and behavior, the povidone ointment group showed improvement to 1.94 (±2.53), 0.61 (±1.34), and 0.39 (±1.24) while the chlorhexidine group showed improvement to 2.00 (±1.6), 0.87 (±0.99), and 0.86 (±0.99) on days 0, 3, and 7 respectively, showing similar improvement in symptoms between the two groups (p>0.05). When observing wound symptoms, most of the swelling and inflammation improved within 3 days. The averages for the chlorhexidine group on days 0, 3, and 7 were 4.88 (±2.85), 2.88 (±2.64), and 2.38 (±2.39), and for the povidone ointment group, 5.55 (±3.22), 3.83 (±3.07), and 1.38 (±1.61), respectively. The wound healing effect of the povidone ointment group was similar to that of the chlorhexidine group (p>0.05). Through this study, we believe that topical povidone ointment can be applied to various wounds by replacing chlorhexidine.
4,000원
8.
2024.03
구독 인증기관 무료, 개인회원 유료
An ameroid constrictor (AC) was placed to occlude the shunt vessel in a dog diagnosed with a single extrahepatic portocaval shunt, and the patient showed favorable outcomes post-surgery. However, the 1-year postoperative assessment revealed that the shunt vessel was completely occluded, but the AC had migrated into the abdominal cavity. The examination of the surgically removed migrated AC revealed an internal space filled with fibrous tissues with no swelling in the casein, and notably, the key remained securely in place. This is the first veterinary medicine case in which migration of the AC without dislodgement of ameroid key was identified.
4,000원
9.
2024.03
구독 인증기관 무료, 개인회원 유료
Scaly-leg in chickens, also known as knemidokoptiasis, is caused by infection with Knemidokoptes spp. Chickens in backyard systems developed scaly skin lesions on their legs. This farm is not an industrialized farm for producing meat or eggs. A skin smear microscopic test identified the Knemidokoptes spp. mites, revealing both larvae and adults in the same chicken. Ivermectin was applied to control the knemidokoptiasis through oral and topical administration. However, there were no clinical effects observed after the application of ivermectin. Knemidokoptiasis worsens the quality of life in chickens. Effective control methods could be established in further studies.
3,000원
10.
2024.03
구독 인증기관 무료, 개인회원 유료
Enterococcus species are considered as parts of the indicator strains for fecal contamination on retail meats because they reside in the gastrointestinal tracts of humans and animals. Frequent acquisition and dissemination of antibiotic resistance genes among enterococci have increased their morbidity and mortality rates and thus become a serious public health issue. For example, vancomycin (Van)-resistant and/or multidrug resistant (MDR) enterococci are increased during recent years. Currently, only a few therapeutic options have been approved for linezolid (LZD), daptomycin (DAP), and tigecycline (TGC) to treat VAN-resistant and/or MDR enterococcal infections. In this review, we have updated the recent status of enterococcal resistance to those three last-resort antimicrobials (LZD, DAP, TGC) among livestock animals and retail meats.
4,000원
