This study proposes a construction plan for the Korea Navy's next-generation TSCE(Total Ship Computing Environment) based destroyers to address rapidly evolving maritime threats and decreasing military manpower. It focuses on system integrated ship construction based on TSCE for quick response time with fewer operators, improving the efficiency of systems and Equipments installed in the ship. The methodology includes analyzing TSCE-based system integration theories and levels. also analyze system integration in U.S. Navy’s Zumwalt destroyers and Littoral Combat Ships, conducting expert surveys to build consensus on system integration methods, proposing operational efficiency improvements through TSCE-based system integration. Additionally, we propose an architecture of TSCE with real time OA(Open Architecture) from both functional and physical perspectives, verified through Python simulations. The study suggests optimal crew sizes for next-generation destroyers through comparative analysis of TSCE based integration types. It emphasizes the importance of system integration in naval ship construction, presenting specific measures to enhance operational efficiency and optimize crew operations. The findings are expected to contribute significantly to enhance the future naval capabilities of the Korea Navy.