With emphasis on native genetic resource, Korean native chicken is one of the major native breeds in poultry in Korea. The weight-age data from 216 pullets of Korean native chicken were used to fit the growth curve using Gompertz model. Live weights have been recorded every three weeks for 36 weeks for 5 strains. All available weight data from birth to the 6 specific ages of week were used for the estimation of parameters. The variation in estimates of mature weight (A) decreased with the increase of age 21 through 36 weeks for all 5 strains studied. However, the variation of rate of maturing (k) showed a tendancy increase with the increase of age. These results indicate that the fitting of growth curve is getting more stable for asymptotic value (A) and more flexible for curve shape (k) with the increase of weight-age data range. Correlations among estimates of A and among estimates of k at various ages showed the highest range of 0.93 ~ 0.99 between 30 and 36 weeks except for the maturing rate (k) of red brown strains. The correlations between A and k tended to fluctuate and were not significant statistically at various ages. Thus, the estimates of growth curve parameters, A and k suitable for genetic studies in Korean native chicken can be derived from accumulated weight-age data after 30 weeks of age.

Bovine viral diarrhea virus (BVDV) is a major pathogen that may be one of the main reasons for economic losses in the livestock industry. BVDV is a well-characterized member of Flaviviridae family with plus-stranded RNA viruses. Non-structural NS5B protein is RNA-dependent RNA polymerase, which is responsible for viral RNA synthesis and genome replication of BVDV. Therefore, the NS5B polymerase is a key target for the discovery of anti-BVDV drugs. A number of small-molecule inhibitors against the NS5B polymerase have been reported in literature of which we collected series molecules having various scaffold with their biological data determined by evident experimental conditions, methods and procedures. Then, we constructed database of 655 small-molecule NS5B inhibitors having definitive activity values, structural parameters, and physicochemical properties (such as molecular hydrophobicity, hydrophilicity, polarity, Hbond donors and H-bond acceptors) associated with their absorption and permeability through a cheminformatics approach. The database was opened to provide insight for allosteric NS5B inhibitors of BVDV with an accessible platform on the web (http://nabic.rda.go.kr/chemical genomic database/BVDV RNA dependent RNA polymerase inhibitors). This molecular information in the database would be useful in attempting to identify features and decision factors that enhance anti-BVDV activity or increase selectivity of the allosteric inhibitor. These anti-BVDV molecules could also be screening for the purpose of exploiting potent NS5B inhibitors in the same family (e.g., HCV, CSFV, YFV, WNV, and DENV).