Fatigue is not a trivial issue and needs much attention. On the other hand, fatigue among seafarers could lead to accidents at sea due to their inability and ineffectiveness in carrying out their work. Some were caused by sleepiness and lack of vigour, which, could not only affect their safety but compromising on other seafarers as well. In this study, factors that cause fatigue among seafarers were examined analytically and their quantitative priorities were determined using Analytic Hierarchy Process (AHP) method. Additionally, the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) is used to identify the best alternatives in minimizing fatigue among seafarers. For this, data is collected through interview involving those working in academic and maritime industry with more than 5 years of experiences in dealing with seafarers. The AHP result shows that fitness is the main cause that could affect fatigue on seafarers’ reliability. Besides, TOPSIS result shows that a well-maintained shipboard is the best way in sustaining seafarers’ energy. In sum, fatigue among seafarers could influence on safety and may lead towards precarious health issue over a long-term.