Tuned Mass Damper (TMD) is a prominent mean of controlling structural vibration. Typically the TMDs are installed at the top of the structure. In this study, the effectiveness of the multiple tuned mass dampers (MTMD) distributed along with the height of structure is investigated for seismic loading. A ten storey building with lateral degree of freedom is modeled with distributed tuned mass dampers in the platform of MatLab R2010a. Though the first mode of a MDOF system dominates in response of the structure, it is also observed that the other mode can also have a significant role in the response reduction. Suitable location for the installation of the TMDs and there tuning frequencies are selected based on the mode shape and frequencies of the uncontrolled structure respectively. It is observed that distributed TMD is more effective than Single TMD and Multiple TMD installed at top of the structure in response reduction.