In this study, we conducted laboratory tests to evaluate the moisture resistance of the asphalt mixture containing air-cooled slag. Generally, in Korea, hydrated lime is used up to 1.5% of the aggregate weight to improve the moisture resistance of the asphalt mixture. The slag used in this study is a byproduct produced in the steel industry and can be produced through a specific process. And its chemical composition is similar to that of the hydrated lime stone and satisfies the filler quality standards of the Ministry of Land, Transport and Transport. In order to evaluate the moisture resistance of the asphalt mixture containing air-cooled slag, we conducted the dynamic immersion test, which is a non-compaction mixture test. Also we conducted the indirect tensile strength ratio test and the Hamburg wheel tracking test for compaction asphalt mixture test. As a result of the dynamic immersion test, the effect of stripping prevention was similar to that of hydrated lime because it did not show much difference from the hydrated lime mixture. In the case of indirect tensile strength test, the specimens prepared in the laboratory and on the site satisfied the quality standards of the Ministry of Land, Transport and Logistics and the TSR value increased with increasing the content of air-cooled slag. However, when the content of air-cooled slag is more than 2%, the indirect tensile strength value is getting lower. So it is judged that the appropriate content should be determined to be 2% or less. In the case of the Hamburg wheel tracking test, when the steel wheel load passed 20,000 times on the asphalt mixture containing 2% of air-cooled slag, it showed 5.27mm deformation. And the stripping point was not observed. In this study, it was found that when the air-cooled slag is used as a substitute for hydrated lime, the moisture resistance of the asphalt mixture can be improved. It is considered that the aircooled slag can be used for the asphalt pavement material through the characteristics analysis of mechanical and field application in the future