Canine hyperadrenocorticism, a prevalent endocrine disorder characterized by excessive cortisol production. Notably, hypercoagulability leading to pulmonary thromboembolism (PTE) poses a substantial concern. PTE may be underestimated because of the rapid dissolution of canine thrombi postmortem. However, traditional coagulation assays face challenges in early detection of hypercoagulability. Therefore, this study explored the use of thromboelastography (TEG) as a diagnostic tool for identifying hypercoagulability in dogs with hyperadrenocorticism. A total of 31 dogs visited the Gyeongsang Animal Medical Center between 2018 and 2022, comprising 21 dogs with hyperadrenocorticism and 10 controls who underwent clinical and coagulation analyses. Hyperadrenocorticism was diagnosed using a low-dose dexamethasone stimulation test or adrenocorticotropin hormone stimulation test, and conventional laboratory parameters and coagulation parameters, such as the prothrombin time, activated partial thromboplastic time, fibrinogen, and TEG results, were compared between the groups. Clinical data revealed significantly elevated monocyte, platelet, alanine aminotransferase, alkaline phosphatase, triglyceride, and cholesterol concentrations in dogs with hyperadrenocorticism, which were attributed to excess cortisol secretion (p<0.05). TEG analysis demonstrated significantly decreased K values and increased α and MA values in hyperadrenocorticism dogs (p<0.05), indicating a shortened clotting time and enhanced clot strength, suggestive of hypercoagulability. TEG effectively highlights hypercoagulability in dogs with hyperadrenocorticism and provides valuable insights in predicting blood clot formation. Although predicting clot formation in dogs remains complex owing to multifactorial influences, this study underscores the potential utility of TEG in enhancing such predictions for dogs with hyperadrenocorticism.

본 연구는 서해에 위치한 영광 연안해역의 해양수질환경 및 해저퇴적물 환경을 파악하여 기초자료로 제공하고자 한다. 영광 안마도 인근 해역의 21개 정점을 선정하여 2020년 7월에 조사를 실시하였다. 표층해수는 고무 용질의 소형바스켓, 저층은 Van Dorn 채수기를 이용하여 채수하였고, 퇴적물은 Van Veen grab sampler로 채취하였다. 분석항목은 수온, 염분, DO, COD, 영양염류 등 13개의 항목이며, ‘해양환경공정시험기준(해양수산부, 2019)’에 준하여 분석을 실시하였다. 수온은 21.20 ~ 24.20℃, 염분은 31.35 ~ 32.53 psu, 수소이온농도 는 7.62 ~ 8.06, 투명도는 0.20 ~ 3.10 m, 부유물질 농도는 47.00 ~ 455.20 mg/L, COD의 경우에는 0.42 ~ 3.78 mg/L, Chl-a는 0.70 ~ 5.51 μg/L, 용존 무기질소는 0.28 ~ 4.17 uM, 인산은 0.24 ~ 1.14 uM, 규산 규소는 16.28 ~ 35.35 uM, 총 질소는 0.186 ~ 0.542 mg/L, 총 인의 경우 0.037 ~ 0.111 mg/L 의 범위를 나타내었다. 퇴적물 COD의 경우 일본수산용수기준치인 20 mg/g-dry(일본수산자원보호협회편, 2000)보다 낮은 값을 나타내었다. 또한 주성분 분석을 실시하여 해역의 특성을 파악하였다.