Objectives: Lipoma is the most common soft tissue mesenchymal tumor which grows slowly. [1] [2] Intraoral lipomas are rare and have been reported in approximately 1 to 4% of all neoplasm in various literature. [2-5] Oral lipomas mostly develop slowly without symptoms, [6] and predominantly affect the buccal mucosa, floor of mouth, tongue and lip. [3] Material and Methods: A 71-year old male presented with asymptomatic swelling on tongue. On the clinical examination, there were various size of three swelling areas on the dorsum of tongue. Result: All lesions were surgically removed via intraoral approach under general anesthesia. They were soft and yellowish in color. All of the specimens has histologically revealed as typical lipomas. Conclusion: It is a report of tongue lipomas as a rare site, with clinical, histological and radiographic features. Also, there were several reports of a large or huge lipoma in oral cavity, however there were no report of multiple lipomas on the tongue. So, authors report the rarity of it.

The case of an intraosseous leiomyoma in a 22-year-old man is presented. The tumor was incidentally discovered during dental radiographic examination for endodontic treatment of mandibular first molar. Radiographic examination revealed a well-defined unilocular radiolucency between the roots of mandibular left canine-first premolar, measuring approximately 1.9 x 1.8 cm and perforation of the buccal cortical plate. Histological and immunohistochemical examination was diagnostic of intraosseous solid leiomyoma. Here, we report a rare case of leiomyoma of the mandible, together with conventional histopathologic and immunohistochemical findings.

Dentin, a major component of teeth, is formed by odontoblasts which produce the dentin matrix beneath the dental epithelium and induce the mineralization of dentin. To date, the biochemical properties of dentin matrix proteins have been well characterized, but upstream regulators of these proteins are not yet well known. Recently in this regard, several transcription factors have been identified as potential regulators of matrix proteins. Most transcription factors are generally involved in diverse biological processes and it is essential to identify those that are odontoblast-specific transactivators to further understand the process of dentin formation. We thus analyzed the expression pattern of dentin matrix proteins and the activities of established transactivators containing a Cre-locus. Expression analyses using in situ hybridization showed that dentin matrix proteins are sequentially expressed in differentiating odontoblasts, including type-I collagen, Dmp-1 and Dspp. The activities of the transactivators were evaluated using β-galactosidase following the generation of double transgenic mice with each transactivator and the ROSA26R reporter line. The β-galactosidase activity of each transactivator paralled the expression of the matrix proteins. These results thus showed that these transactivators could be utilized for odontoblastspecific conditional gene targeting. In addition, time- and tissue-specific conditional gene targeting might also be achieved using a combination of these transactivators. Odontoblast-specific conditional gene targeting with these transactivators will likely also provide new insights into the molecular mechanisms underlying dentin formation.