Objectives: Lipoma is the most common soft tissue mesenchymal tumor which grows slowly. [1] [2] Intraoral lipomas are rare and have been reported in approximately 1 to 4% of all neoplasm in various literature. [2-5] Oral lipomas mostly develop slowly without symptoms, [6] and predominantly affect the buccal mucosa, floor of mouth, tongue and lip. [3] Material and Methods: A 71-year old male presented with asymptomatic swelling on tongue. On the clinical examination, there were various size of three swelling areas on the dorsum of tongue. Result: All lesions were surgically removed via intraoral approach under general anesthesia. They were soft and yellowish in color. All of the specimens has histologically revealed as typical lipomas. Conclusion: It is a report of tongue lipomas as a rare site, with clinical, histological and radiographic features. Also, there were several reports of a large or huge lipoma in oral cavity, however there were no report of multiple lipomas on the tongue. So, authors report the rarity of it.

The case of an intraosseous leiomyoma in a 22-year-old man is presented. The tumor was incidentally discovered during dental radiographic examination for endodontic treatment of mandibular first molar. Radiographic examination revealed a well-defined unilocular radiolucency between the roots of mandibular left canine-first premolar, measuring approximately 1.9 x 1.8 cm and perforation of the buccal cortical plate. Histological and immunohistochemical examination was diagnostic of intraosseous solid leiomyoma. Here, we report a rare case of leiomyoma of the mandible, together with conventional histopathologic and immunohistochemical findings.

Genomic imprinting is defined as parent-of-origin expression of specific genes and may play an important role in embryonal development of mammals. Loss of imprinting(LOI), biallelic expression of the imprinted genes, have been observed in a variety of human tumors and syndromes. H19, a paternally imprinted gene, is transcribed as an untranslated RNA that serves as a riboregulator. LOI of H19 is observed in a variety of human malignancies. In this study, LOI of H19 was examined in head and neck squamous cell carcinomas(HNSCCs). Four(28.6%) of the 14 HNSCCs and 8(28.6%) of the 28 inflammatory oral lesions were informative for imprinting analysis of H19. H19 was imprinted in all inflammatory oral lesions, however, 2(50%) of the 4 informative HNSCCs manifested LOI. These data suggest that LOI of the H19 may play a role in the oncogenesis of HNSCC.