Periodontitis and periimplantitis are caused as a result of dental biofilm formation. This biofilm is composed of multiple species of pathogens. Therefore, controlling biofilm formation is critical for disease prevention. To inhibit biofilm formation, sugars can be used to interrupt lectin-involving interactions between bacteria or between bacteria and a host. In this study, we evaluated the effect of D-Arabinose on biofilm formation of putative periodontal pathogens as well as the quorum sensing activity and whole protein profiles of the pathogens. Crystal violet staining, confocal laser scanning microscopy, and scanning electron microscopy revealed that D-Arabinose inhibited biofilm formation of Porphyromonas gingivalis , Fusobacterium nucleatum , and Tannerella forsythia . D-Arabinose also significantly inhibited the activity of autoinducer 2 of F. nucleatum and the expression of representative bacterial virulence genes. Furthermore, D-Arabinose treatment altered the expression of some bacterial proteins. These results demonstrate that D-Arabinose can be used as an antibiofilm agent for the prevention of periodontal infections.

Phenolic compounds are naturally occurring secondary metabolites from various plants. These compounds play important roles in plant such as antioxident, antibacterial and anticancer effects. The purpose of this research was to analyze the phenolic compounds contents in Kenaf leaf and stem using High Performance Liquid Chromatograpy. Kenaf is widely distributed throughout the country and third largest fiber crop. Recently, interest in this crop is growing. But, there is little research on their functional material. The obtained results showed that phenolic compounds were significantly various among the examined cultivars of Kenaf. Especially, phenolic compounds contents of leaf were higher than those of stem. The highest concentration of phenolic compounds was in the E41 leaf(24358.99㎍/g) and the lowest concentration was in the Kenaf (in korea) stem(988.21㎍/g). The results of this experiment showed that its contents were different in leaf and stem. These results suggested that Kenaf can be used for functional plant.