With the wave of digital economy sweeping the world, artificial intelligence, blockchain, cloud computing, 5G, ChatGPT and other information technologies are developing rapidly. All walks of life are undergoing changes, and people’s thinking, cognition, life, study, and work are changing accordingly. Both developed and developing countries are also facing new situations and challenges in politics, economy, science and technology, culture, and education. It can be said that digitalization itself and its impacts are related to the development of the future world and affect every citizen of the earth. Digital literacy and skills derived from digitalization have gradually become the focus of attention from all walks of life. In terms of college students’ digital literacy and digital literacy skills, it mainly refers to the digital ability that college students should have and use in study, employment, and future work under the background of informatization and digitalization. Although digital literacy and digital literacy skills have been paid more and more attention by the international community and schools, there is no unified definition of digital literacy and digital literacy skills by various countries and international organizations, and there are some differences in the use of this concept by countries and regions. From the perspective of enterprises’ demand for digital talents, this paper puts forward some suggestions on the training and improvement of college students’ digital literacy skills.