Changing climate, especially water content(WC) and CO2 (CD) concentration could be effect on the growth of soybean and seed yield. So we evaluated the effects of WC and CD on the physiological characteristics of newly developed soy cultivars in growth chamber. Ten soy cultivars evaluated in three [CO2] levels (CD1, 350; CD2, 500; CD3, 700ppm) and three water content (WC1: 30%, WC2: 40, WC3: 50%) in the pot in growth chamber. Increased [CO2] from 350 to 500 and 500 to 700ppm enhanced crop growth parameters greatly and grain yield, however, grown in CD3 enhanced plant height increasing speed, and shortened growing duration, however, they were grow very weakly and it resulted in lodging problem. High soil water content (WC3) hampered growth and yield of soybean in three CD treatments and the degree was lower in CD1 and CD2 than CD3. In this results we can conclude increasing [CO2] in Korean peninsular might be decrease lodging resistance, especially high moisture content, so, plant breeders and physiologists need to develop improved lodging resistance cultivars under high water content and high CO2 content.