In recent years, the bilateral relations between the United States and Vietnam have shown a momentum of rapid development. The year 2020 marks the 25th anniversary of the normalization of bilateral relations between the two countries. Through sorting out the effects, problems and development trends of the comprehensive partnership between the two countries, this paper discusses the factors restricting the development of the bilateral relations, and then analyzes the prospects of the development of the US-Vietnam relations. The United States and Vietnam have a number of strategic convergence points to deepen cooperation, but at the same time, the two countries still face challenges in ideology, political system and other aspects. In the future, it is possible for the US-Vietnam relationship to continue to strengthen. On the one hand, Vietnam will strengthen bilateral relations with the US and implement multilateralism diplomacy to contain China. On the other hand, Vietnam will avoid stimulating China and stabilize its relations with China.