In the process of China’s modernization of social and economic development, China has gradually expanded the scope of foreign trade, especially the deepening of economic and trade cooperation with South Korea, and the steady growth of bilateral trade and investment. However, during this period, it will be affected by internal and external factors, leading to the increasing trade deficit between China and South Korea. The frequent occurrence of trade friction has caused a serious impact on the economic and trade development of China and South Korea. Therefore, in the actual work, it is necessary to respond flexibly to the challenges, meet the opportunities and adopt scientific countermeasures according to the development status of Sino-South Korea economic and trade cooperation, so as to promote the continuous progress of the two countries’ economic and trade.