Trans-Pacific Partnership Agreement (TPP), known as the ‘economic’ NATO Agreement dominated by the United States, will impose profound influence on the politics, economy, society and intellectual property system in China. There are deep-seated reasons why the US are extremely active to make TPP signed and why China is ruled out in the course of the negotiations. Since China has entered into the WTO, the domestic and international market is closely related, and TPP must have significant impact on China’s international market. With regard to the influence, China shall take efficient measures to cope with, including: dealing with issues appropriately regarding its economic sovereignty, based on its own situations, promoting of negotiations on free trade agreement, keeping on improving the hard and soft power in intellectual property, fully taking advantages of “the Belt and Road Strategy” and exploring new market; and getting ready for constant adaptation to TPP rules and the like.