The observations on the seasonal fluctuation and distributional characteristic of organic matters on surface sediments and its origin were carried out at the 25 stations in Keogeum-sudo, southern coast of Korean Peninsula from February to October in 1993. I made an analysis on the environmental factors for surface sediments such as temperature, ignition loss, chemical oxygen demand, pheopigment, total sulphide, water content, mud content in grain size, COD/IL ratio and COD/sulphide ratio. The results are as follows ; 1) The range of temperature on the surface sediments was between 6.2℃ and 24.6℃. The highest mean temperatuer of mud was 24.0℃ in summer, the lowest 6.6℃ in winter. 2) Ignition loss(IL) fluctuated between 1.2% in winter and 16.8% in spring, that is to say, the seasons of increasing in temperature were very high ignition loss. 3) Chemical oxygen demand(COD) showed the highest mean value of 20.52 ㎎/g dry in summer within the range of 15.46∼32.78 ㎎/g dry, while showed the lowest of 5.79 ㎎/g dry in winter within the range of 7.4∼17.39 ㎎/g dry. 4) Pheopigment concentrations showed the highest mean value of 4.85 ㎍/g dry in autumn within the range of 0.84∼9.21 ㎍/g dry, while it did the lowest mean value of 1.97 ㎍/g dry in summer within the range of 0.23∼4.83 ㎍/g dry. 5) Total sulphide (H2S) fluctuated between no detect(ND) in spring, and 2.43 ㎎/g dry in autumn. The highest mean value was 0.68 ㎎/g dry in autumn, the lowest was 0.16 ㎎/g dry in spring. 6) Water content(WC) and mud content in grain size showed the mean value of 43.2% within the range of 26.5∼59.7% and 91.0% within the range of 57.8∼99.2%, respectively. 7) By the analytical results on the source of organic matter, it had been dumped from the seaweed farms in Keogeum-sudo coastal waters.

Now, many anticancer drugs are applying in the clinical side, but there is no conclusive effect of such a chemotherapy. Development ofnovel clinical useful anticancer drugs would be dependenton the screen-ing system and its test sample sources. So, it is necessary to outlinesome background on the tumor systems which have been used for screen-ing. This paper describes mainely on National Cancer Institute (NCI)program for anticancer screening systems, because the large number ofcompounds have been screened at NCI prograB and their relationship ofassesment between experimental animals and clinical Patients has beendiscussing and the uniform screefing protocols for various tumorsystens. At the end of this paper, some literatures of antitunor substances from various higher Plants at our laboratory are showed.