The purpose of this study was to examine the current satisfaction levels with nurse uniforms at Taizhou General Hospital in China and to find areas for improvement in order to develop nurse uniforms with improved comfort, fit and convenience. To investigate satisfaction with nurse uniforms, a survey was conducted of 150 nurses. The general characteristics of the nurses, uniform conditions, feelings of satisfaction, fit, preferred designs, inconvenient aspects of the uniforms, and areas for improvement were analyzed. Eight materials of cotton/polyester blended fabrics were selected according to Chinese nurse uniform regulations, and the physical properties of the materials were tested along with the materials used in current nurse uniforms. Four new nurse uniforms with increased aesthetics, functionality, and comfort were developed based on the survey results. Materials with excellent absorption, moisture permeability, and ventilation were used as main fabrics. According to the preferred designs of nurses at Taizhou City General Hospital, China, 4 types of nurse uniforms designed, consisting of design 1 (shirt and pants), design 2 (shirt and pants), design 3 (dress), and design 4 (shirt and skirt). The new nurse uniforms offered better functionality with an improved fit at the armpits, waist, hips, and knees based on product measurements.