In this study, rational prediction models for the effective compressive strengths of HSC corner and interior columns with intervening NSC slabs are developed. A structural analogy between HSC column-NSC slab joint and brick masonry is used to develop the prediction models. In addition, the aspect ratio of slab thickness to column dimension and the surrounding slab confinement effect are considered in the models. The proposed prediction model is verified by comparison with experimental results and various prediction expressions. As a result, with average test-to-predicted ratios of 1.00 for HSC corner columns and 1.09 for interior columns, the proposed equation provides superior predictions over all of the existing effective strength prediction approaches including KCI structural concrete design code(2012).