The purpose of this study is to understand the formation of internal wind paths of open space and its effect on meteorological factors and the generation of negative air ions. Various types of internal wind paths of open space were formed. Subsequently, changes in meteorological factors in each type were measured and the generated negative air ions were analyzed. The four key findings of the study are summarized as follows. First, the average wind speed formed inside the open space was analyzed such that the difference in wind speed was dependent on the difference in the composition of the wind path. Second, the negative air ion generation was observed to have the same trend as the average wind speed difference. Third, changes to the meteorological factors were more evident depending on the difference in wind path formation patterns. Solar radiation was expected to be highly affected by the physical structure (direction) of the target site. The relative humidity was found to show large difference depending on the different wind path type; however, this difference was significantly reduced when converting to absolute humidity. Fourth, it was found that the wind path formation type of open space affects meteorological factors through path analysis, and the changed meteorological factors affect the amount of generated negative air ions. Two conclusions can be obtained based on these results. First, the changes in internal wind speed formation of open space directly reduced the amount of generated negative air ions. Second, the changes in wind speed affect meteorological factors as well as the amount of generated negative air ions.