The purpose of this study was to examine the effects of stress response on safety behavior and to explore moderating effect of safety climate between stress response and safety behavior. 224 workers were asked to respond to the questionnaires that measured various demographic variables, stress response, safety climates and safety behaviors. A hierarchical regression was conducted to identify variables that had significant relationships with safety behavior and to examine moderating effect of safety climate between stress response and safety behavior. Results indicated that the depression response significantly predicted safety behavior. It was found that the safety climate was also a significant predictor for safety behavior. In addition, safety climate had a moderating effect on the relation between depression and anger responses and safety behavior.