The performance of helical hydro turbine in water pipe line depends on the sectional shape of turbine blade, pitch angle of turbine blade, solidity and number of turbine blades, To investigate the effects of these design factors on the performance of helical hydro turbine, flow analysis was carried out by using commercial code ANSYS CFX version 14..5. From CFD analysis we obtained the optimum design factors which were the asymmetric blade shape of NACA4420, the pitch angle of 15 degrees and the solidity of 0.3. These results can be used for the actual design of sphere-shaped helical turbine in water pipe line.