PURPOSES : This study analyzes the accident damage scale of hazardous material transportation vehicles not monitored in real time by the Hazardous Material Transportation Safety (HMTS) management center. METHODS : To simulate hazardous-material transportation vehicle accidents, a preliminary analysis of transportation vehicle registration status was conducted. Simulation analyses were conducted for hazardous substance and flammable gas transportation vehicles with a high proportion of small- and medium-sized vehicles. To perform a spill accident damage-scale simulation of hazardous-substance transportation vehicles, the fluid analysis software ANSYS Fluent was used. Additionally, to analyze explosion accidents in combustible gas transportation vehicles, the risk assessment software Phast and Aloha were utilized. RESULT : Simulation analysis of hazardous material transportation vehicles revealed varying damage scales based on vehicle capacity. Simulation analysis of spillage accidents showed that the first arrival time at the side gutter was similar for various vehicle capacities. However, the results of the cumulative pollution analysis based on vehicle capacity exhibited some differences. In addition, the simulation analysis of the explosion overpressure and radiant heat intensity of the combustible gas transportation vehicle showed that the difference in the danger radius owing to the difference in vehicle capacity was insignificant. CONCLUSIONS : The simulation analysis of hazardous-material transportation vehicles indicated that accidents involving small- and medium-sized transportation vehicles could result in substantial damage to humans and ecosystems. For safety management of these small and medium-sized hazardous material transportation vehicles, it is expected that damage can be minimized with the help of rapid accident response through real-time vehicle control operated by the existing HMTS management center.