A confined space means places where the risk of damage to health caused by lack of oxygen or hazardous gases in inadequate ventilation conditions and the risk of fire and explosion caused by flammable substances. Asphyxiation accidents in a confined space occured every year and also occurred more than two people at the same time. In this study, we surveyed the domestic statistical data occurred the lack of oxygen in confined space for the last 10 years(2006-2015) and, analyzed the accident by industries sector, workplace size etc. 17 fatal work accidents that occurred in confined spaces in Korea between 2013 and 2015 were investigated and analyzed using the database of the KOSHA and suggested interventions to minimize asphyxiation accidents in confined spaces. This paper is expected to be used to establish interventions planning and training as a preventive measures in workplace having confined spaces.