The operating parameters considered in this study include evaporating and condensing temperature, degree of subcooling and degree of superheating. in R744-R717 cascade refrigeration system and R744 two-stage compression refrigeration system with the range of low temperature -50℃∼-30℃. The coefficient of performance(COP) of R744-R717 cascade refrigeration system is about 16∼20% greater than that of R744 two-stage compression refrigeration system in the range of evaporation temperature of -50℃∼-30℃. R744 two-stage compression refrigeration system is unstable because its coefficient of performance changes significantly depending on the evaporating temperature and total compression work, and compression efficiency decreases. In this case, not efficient for long-term use. Whereas R744-R717 R744-R717 is a cascade refrigeration system using eco-friendly refrigerants. And this system is a high-efficiency refrigeration system that performs well even under various operating conditions. This is why it can be configured by selecting a refrigerant suitable for the high temperature side and the low temperature side.