Some Spent Fuel Pools (SFPs) will be full of Spent Nuclear Fuels (SNFs) within several years. Because of this reason, transporting the SNF from SFP to interim storage facilities or permanent disposal facilities should be considered. There are two ways to transport the SNF from a site to other site, one is the land transportation with truck or train, and the other is the maritime transportation with ship. The maritime transportation has some advantages compared with the land transportation. The maritime transportation method uses safer route which is far from populated area than land transportation method, and transport more weight than land transportation method. However, the cask should be loaded into the ship for the maritime transportation, and there is a possibility of a drop accident of the cask onto the ship. Therefore, it is necessary to evaluate the structural integrity of the cask and ship for the drop accident during the loading process. To evaluate the structural integrity of the cask and ship, it is necessary to determine the analysis conditions that caused the greatest damage in the drop accident. There may be various conditions such as the drop angle of the cask, the initial falling speed, the drop position onto the ship, the size of the ship, etc. This study set the drop angle of the cask and the drop position onto the ship as the simulation variables, which have high possibility to occur during cask drop. However, the others are excluded since they are controllable by worker. In this paper, various drop angle (0, 15, 30, 45, and 70 degree) of the cask were simulated to define the greatest damage condition. KORAD-21 cask model was used for Finite Element Analysis (FEA), and FEA was performed to simulate a horizontal drop (1 m drop). The strain-hardening material properties for the deck were used as HT36 steel. The Cowper-Symonds constitutive model for HT36 was used to consider the strain rate effect. A Tie-down structure for supporting the cask was modeled with the cask model which contained inner structures like canister, basket, etc. Structural integrity of the cask and tie-down structure were evaluated using the von-Mises stress and equivalent plastic strain (PEEQ), and one of the ship deck was evaluated using deflection of ship deck and equivalent plastic strain. Compared with each cask drop angle conditions, 45 degree of the cask drop angle showed the highest deflection and PEEQ values, but did not exceed ultimate strain of HT36. In the ship deck, the corner of deck showed the highest PEEQ value in all simulation cases. As the result, the 45 degree of the cask drop angle condition results was more conservative than other conditions, and the corners of deck failure was able to evaluate ship safety.