Regional air quality regulation is a system that allows the Minister of Environment to designate the local area as air quality control region where the concentrations of air pollutants are exceeding the environmental standards, and the local governments that administrate the regulated area have to develop and practise a plan for reducing the air pollutants. From the data observed yearly by the monitoring stations in 8 provincial cities with more than 0.5 million people was judged the compliance with air quality standards in each municipality for the period of 2003 to 2013. As the result of investigation on air pollutants concentrations of each city, it was found that there was no station that exceeds the ambient air quality standards of CO, SO2 and 24-hour NO2. But all municipalities exceeded the standards of 8-hour O3, annual and 24-hour PM10, and therefore 8 municipalities can be designated to be under the local air regulation. For the annual NO2 were the monitoring sites necessary requirements for designation of the air quality regulation region in Cheongju, Cheonan, Daejeon and Gwangju area. Incase of 1-hour O3, some of stations in Pohang, Cheongju, Cheonan and Changwon area were over the designation standards for the air quality control region.