Radioactive materials from nuclear power facilities can be released into the atmosphere through various channels. Recently, the dispersion of radioactive materials has become critical issue in Korea after Kori Unit 1 and Wolsong Unit 1 were permanently shut down. In this study, annual atmospheric dispersion factors were compared based on the continuous release and purge release using the XOQDOQ computer program, a method for calculating atmospheric dispersion factors at commercial nuclear power stations. The meteorological data analyzed in this study was based on the Shin Kori nuclear power meteorological tower which has the largest operating nuclear power plants in Korea, for three years (from 2008 to 2010). The analysis results of the dispersion factor of the radioactive material release obtained using the XOQDOQ program showed that the difference between the continuous release and purge release was within two times. This study will be valuable helpful for revealing the uncertainty of the predictive atmospheric dispersion factor to achieve regulation.