본 연구는 아토피 피부염을 갖는 질환동물에서 어성초를 비롯한 다양한 식물추출물을 이용하여 제조한 크림의 항아토피 피부염증에 대한 효능을 평가하였다. BALB/c 마우스 를 이용하여 아토피 피부염 유발 대조군 및 크림 처리군으로 완전 임의 배치하였다. 혈액 IgE와 히스타민 농도는 크림 처리군이 DNCB 유도 아토피 대조군에 비해서 유의하게 감소하였으며, 아토피 피부염이 심각한 상태의 마우스에서 정상적인 피부상태로 회복되었음을 관찰하였다. 본 결과는 아토피질환 모델 BALB/c 마우스에서 어성초 혼합 식물추출물의 투여가 혈액 IgE를 낮춤과 동시에 비만세포에서 생성되는 히스타민의 배출량을 억제함으로써 항아토피 효능을 갖는다는 점을 시사 해준다.

Photodynamic therapy is a non-invasive cancer therapy that has recently attracted much attention in the field of cancer treatment. This study is an experiment to observe the effect of laser dose difference in photodynamic therapy. Murine breast cancer cells, EMT6 cells, were used to generate tumor bearing mouse models. The experimental group was divided into 5 groups as control group, laser 100 J/cm2, 200 J/cm2, 300 J/cm2 and 400 J/cm2 irradiation group. Photofrin was administered intraperitoneally and after 48 hours, laser irradiated on tumor with energy 0-400 J/cm2. the tumor volume was measured with a digital caliper on day 0, day 2, day 4, day 8 and day 12. The volume of tumor after photodynamic therapy was increased in the control group, laser 100 J/cm2 irradiation group and laser 200 J/cm2 irradiation group until day 12 after irradiation. Both the laser 300 J/cm2 irradiated group and the laser 400 J/cm2 irradiated group showed a decrease in the tumor volume from 2 to 12 days after irradiation. These results suggested that treatment effect will be obtained at a dose of 300 J/cm2 or more in the experiment using the tumor bearing mouse model and photoprin.