Behcet’s disease (BD) is characterized by oral or orogenital ulcers and various systemic symptoms. Ankylosing spondylitis (AS), a prototype of the seronegative spondiloarthropathy(SNSpA) group, is a chronic inflammatory disease of the axial skeleton primarily involving the sacroiliac joint and vertebrae. Coexistence of BD and AS has rarely been reported. We report on a patient with concomitant AS and BD who was treated successfully with etanercept. Several case reports suporting the effectiveness of other medications such as NSAIDs in patients with coexisting AS and BD have been reported in the literature. However, we found no report regarding the use of anti TNF-α agent for treatment of these patients except for one case of adalimumab. To be best of our knowledge, this is the first case of a patient with concomitant AS and BD treated with etanercept.