Oral-derived bioresources(ODBs) for human-derived material research have been mainly sampled by individual researchers. Difficulties in ODB secure has impeded advances in dental research and associated industries. ODBs have been obtained in a few biobanks within general hospitals, yet the amount of oral-derived specimens is relatively low compared to other organs and lacked practical clinical data. Recently, biobanks of dental hospitals have started systematic management in South Korea, thus these biobanks are expected to invigorate high-quality ODB banking in the field. In this review, we will discuss the collection and utilization of OBDs, such as teeth, dental plaque, gingival crevicular fluid and saliva, and the need of dental hospital-based biobanks.